Evidence map›Paper›PMID 41279092›Full record

ArticlebioRxiv : the preprint server for biology2025

Mapping unsolved lipidomes accelerates lipid discovery in major bacterial pathogens.

Yashodhan M Nair, Aruna R Menon, Zonghao Lin, Michiel R L Vossenberg, Vanisha Munsamy-Govender, David C Young, Ana M Xet-Mull, Gregory H Babunovic, Tan-Yun Cheng, Sahadevan Raman and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yashodhan M NairDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School; Boston, MA 02115, USA.
Aruna R MenonDepartment of Molecular Genetics and Microbiology, Duke University; Durham, NC 27710, USA.
Zonghao LinStratingh Institute for Chemistry, University of Groningen; Groningen, 9747 AG, The Netherlands.
Michiel R L VossenbergStratingh Institute for Chemistry, University of Groningen; Groningen, 9747 AG, The Netherlands.
Vanisha Munsamy-GovenderLaboratory of Host-Pathogen Biology, The Rockefeller University; New York City, NY 10065, USA.
David C YoungDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School; Boston, MA 02115, USA.
Ana M Xet-MullDepartment of Molecular Genetics and Microbiology, Duke University; Durham, NC 27710, USA.
Gregory H BabunovicDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School; Boston, MA 02115, USA.
Tan-Yun ChengDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School; Boston, MA 02115, USA.
Sahadevan RamanDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School; Boston, MA 02115, USA.
Kyu Y RheeDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College; New York City, NY 10065, USA.
Jeremy M RockLaboratory of Host-Pathogen Biology, The Rockefeller University; New York City, NY 10065, USA.
Annemieke de JongDepartment of Dermatology, Columbia University Irving Medical Center; New York City, NY 10032, USA.
Adriaan J MinnaardStratingh Institute for Chemistry, University of Groningen; Groningen, 9747 AG, The Netherlands.
Jacob A MayfieldDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School; Boston, MA 02115, USA.
David M TobinDepartment of Molecular Genetics and Microbiology, Duke University; Durham, NC 27710, USA.
D Branch MoodyDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School; Boston, MA 02115, USA.

Funding

Study of M. tuberculosis under human host selection to identify virulence and barrier lipids (Project 1)U19AI162584 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WOOD, ROBIN · 2021 to 2025
$13.5M
T cell response to CDI-restricted lipids in tuberculosisR01AI049313 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2001 to 2025
$10.6M
Macrophage Reprogramming During Granuloma Formation in the ZebrafishR01AI130236 · NIAID · DUKE UNIVERSITY · PI David M. Tobin · 2017 to 2026
$4.5M
Genetic dissection of angiogenesis in the tuberculous granulomaR01AI125517 · NIAID · DUKE UNIVERSITY · PI David M. Tobin · 2017 to 2026
$4.4M
Chemical Biological Discovery of Lipid Virulence Factors in the Major Bacterial PathogensR01AI165573 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2022 to 2025
$3.0M
Activation of human CD1a-restricted T cells by bacterial and mitochondrial lipidsR21AI185955 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Annemieke de Jong · 2025 to 2026
$420k
The Sigma factor SigE's role in mycobacterial granulomasF31AI179076 · NIAID · DUKE UNIVERSITY · PI Aruna Rajendran Menon · 2024 to 2026
$128k
NIAID NIH HHS F31 AI179076NIAID NIH HHS R01 AI049313NIAID NIH HHS R01 AI125517NIAID NIH HHS R01 AI130236NIAID NIH HHS R01 AI165573NIAID NIH HHS R21 AI185955NIAID NIH HHS U19 AI162584
6 · The paper itself

Abstract

Unlike gene-first approaches to understanding bacterial pathogenesis, molecule-forward discovery can uncover unexpected chemical diversity. Here, new lipidomic analytical methods and quality metrics defined the large scope of unknown lipids in the world's deadliest pathogen,

Identifiers

PMID41279092
PMCPMC12637418

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.