Evidence mapPaperPMID 41279134Full record

ArticlebioRxiv : the preprint server for biology2025

A biased allosteric modulator functions as a molecular glue to induce β

Jiemin Shen, Teja Nikhil Peddada, Konstantin E Komolov, Francesco De Pascali, Alexander M Garces, Haoqing Wang, Michael T Lerch, Jeffrey L Benovic, Jun Xu, Brian K Kobilka

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiemin ShenDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.ORCID 0000-0002-3977-0681
Teja Nikhil PeddadaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.ORCID 0000-0002-5132-2064
Konstantin E KomolovDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0001-6799-4626
Francesco De PascaliDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-5880-3725
Alexander M GarcesDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0003-0160-2487
Haoqing WangDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.ORCID 0000-0003-0277-3018
Michael T LerchDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-8173-4879
Jeffrey L BenovicDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Jun XuDepartment of Medical Neuroscience, SUSTech Homeostatic Medicine Institute, School of Medicine, Institute for Biology Electron Microscopy, Southern University of Science and Technology, Shenzhen, Guangdong, 518067, China.ORCID 0000-0002-1600-583X
Brian K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.ORCID 0000-0001-5958-3990

Funding

The Stanford-SLAC CryoEM CenterR24GM154186 · STANFORD UNIVERSITY · 2025 to 2025
$6.5M
Novel Biased Beta2-AR Ligands as Asthma TherapeuticsR01AI161296 · DUKE UNIVERSITY · 2025 to 2025
$630k
G protein coupled receptor structure, dynamics, and signaling.R35NS137408 · STANFORD UNIVERSITY · 2025 to 2025
$628k
NHLBI NIH HHS P01 HL114471NIAID NIH HHS R01 AI161296NIGMS NIH HHS R01 GM083118NIGMS NIH HHS R01 GM135581NIGMS NIH HHS R24 GM154186NIH HHS S10 OD025260NINDS NIH HHS R35 NS137408
6 · The paper itself

Abstract

Family A G-protein coupled receptors (GPCRs) are typically described as monomers, yet growing evidence suggests they can form dimers with distinct signaling properties

Identifiers

PMID41279134
PMCPMC12633310

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.