ArticlebioRxiv : the preprint server for biology2025
Cingulate-centered flexible control: physiologic correlates and enhancement by internal capsule stimulation.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The flexible deployment of cognitive control is essential for adaptive functioning in dynamic environments given limited cognitive resources. That flexibility depends on rapid detection and resolution of control-prediction errors (CPEs) when current demands diverge from the control plan. Deficits in control and control flexibility are common in psychiatric disorders, yet targeted interventions are limited by incomplete circuit-level understanding and limited means for modulating control circuits . We analyzed two intracranial electroencephalography datasets (one with brief internal capsule stimulation, ICS) to identify a human neurocomputational mechanism for CPE resolution and to test its modifiability. A third dataset of patients receiving internal capsule deep brain stimulation (IC DBS) assessed clinical relevance of modifying CPE-related processes. Phase-amplitude coupling (PAC) anchored to the θ phase of right rostral anterior cingulate cortex (rACC-R), especially θ-
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