Evidence map›Paper›PMID 41279261›Full record

ArticlebioRxiv : the preprint server for biology2025

Long-Term Intestinal Epithelial Remodeling Induced by Acute Protein-Energy Malnutrition.

Fenja A Schuran, Neha Mishra, Víctor A López-Agudelo, Nina Sommer, Joana P Bernardes, Alesia Walker, Finn Hinrichsen, Ting Gong, Felix Gilbert, Lena Schröder and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Fenja A SchuranInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Neha MishraInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Víctor A López-AgudeloInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Nina SommerInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Joana P BernardesInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Alesia WalkerResearch Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
Finn HinrichsenInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Ting GongInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Felix GilbertInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Lena SchröderInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Archana BhardwajInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Sven KünzelMax-Planck-Institute for Evolutionary Biology, August-Thienemann-Straße 2, 24306 Plön, Germany.
Saskia Weber-StiehlInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Go ItoDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, 2 Chome-12-1 Ookayama, 152-8550, Tokyo, Japan.
Florian TranInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Matthieu GroussinInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.
Christoph RöckenDepartment of Pathology, Christian-Albrechts-University, University Hospital Schleswig-Holstein, 24105, Kiel, Germany.
Juan MatuteGastroenterology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston MA 02115, USA.ORCID 0000-0002-1703-8115
Stefan SchreiberDep. of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, 24105 Kiel, Germany.
Josef M PenningerDepartment of Laboratory Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Richard S BlumbergGastroenterology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston MA 02115, USA.
Philippe Schmitt-KopplinResearch Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
John F BainesMax-Planck-Institute for Evolutionary Biology, August-Thienemann-Straße 2, 24306 Plön, Germany.
Felix SommerInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.ORCID 0000-0002-6545-3487
Philip RosenstielInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Rosalind-Franklin-Straße 12, 24105 Kiel, Germany.

Funding

Endoplasmic reticulum stress and intestinal inflammationR01DK088199 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg · 2010 to 2026
$9.6M
NIDDK NIH HHS R01 DK088199
6 · The paper itself

Abstract

Protein-energy malnutrition (PEM) is a global health burden with lasting effects that extend well beyond the initial nutrient deficiency. To systematically investigate the long-term effects of a single episode of PEM on the structure and function of the intestinal epithelium and its associated microbiota, we employed a comprehensive multi-omics approach, including (spatial) transcriptomics, DNA methylation analysis, fecal metagenomics, and metabolomics. Our findings show that PEM persistently alters the intestinal epithelium by depleting Paneth cells and suppressing antimicrobial gene expression - changes linked to DNA methylation that persist despite dietary recovery. In germ-free mice, the sustained epithelial phenotype after was absent. We identified the microbial lipid metabolite 9-HODE and epigenetically deregulated PPAR-driven GDF15 expression as key molecular drivers of the persistent PEM-induced Paneth cell dysfunction. Targeting microbial lipid production and its link to the host GDF15 pathway could offer novel therapeutic strategies for long-term consequences of malnutrition and other Paneth cell-associated diseases.

Indexed as

GDF15intestinal epitheliumintestinal inflammationmicrobiomePaneth cellProtein energy malnutrition

Identifiers

PMID41279261
PMCPMC12633548

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.