Evidence map›Paper›PMID 41279310›Full record

ArticlebioRxiv : the preprint server for biology2025

Dynamical memory underlies prolonged plasmid persistence after transient antibiotic treatment.

Zhengqing Zhou, Andrea Weiss, Zhixiang Yao, Xiaoli Chen, Kristen Lok, Hye-In Son, Lingchong You

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhengqing ZhouDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Andrea WeissDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Zhixiang YaoDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Xiaoli ChenDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Kristen LokDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Hye-In SonDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Lingchong YouDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.

Funding

Post-antibiotic effect and design of optimal antibiotic dosing protocolsR01GM098642 · NIGMS · DUKE UNIVERSITY · PI YOU, LINGCHONG · 2011 to 2025
$3.6M
Tradeoffs between fitness costs and transfer rates in horizontal gene transferR01AI125604 · NIAID · DUKE UNIVERSITY · PI LINGCHONG YOU · 2017 to 2026
$3.3M
Targeted control of self-transmissible plasmids by using engineered interfering plasmidsR01EB031869 · NIBIB · DUKE UNIVERSITY · PI YOU, LINGCHONG · 2021 to 2024
$1.5M
NIAID NIH HHS R01 AI125604NIBIB NIH HHS R01 EB031869NIGMS NIH HHS R01 GM098642
6 · The paper itself

Abstract

Plasmids play critical roles in spreading and maintaining antimicrobial resistance (AMR). They often exhibit prolonged persistence upon antibiotic treatment, even when they impose substantial burden on their hosts. This persistence has been primarily attributed to rapid horizontal transfer or low plasmid cost. However, these mechanisms cannot account for the slow decay of burdensome plasmids with poor mobility. Here, we show that the decoupling of time scales between slow segregation loss and fast growth competition leads to a slow-down in plasmid abundance decay at high initial plasmid abundance, reminiscent of the

Identifiers

PMID41279310
PMCPMC12637634

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.