Evidence map›Paper›PMID 41279338›Full record

ArticlebioRxiv : the preprint server for biology2025

Disruption of Marrow Microenvironments in Chronic Lymphocytic Leukemia by High-Resolution Synchrotron Micro-Computed Tomography.

In Kyu Lee, Yoshihiro Obata, Anthony D Pomicter, Justin A Williams, Bejal Kikani, Christopher E Jensen, Douglas W Sborov, Deborah M Stephens, Claire Acevedo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

In Kyu LeeDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, 92093, CA, USA.ORCID 0000-0001-5554-808X
Yoshihiro ObataDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, 92093, CA, USA.
Anthony D PomicterHuntsman Cancer Institute, University of Utah, Salt Lake City, 84112, UT, USA.
Justin A WilliamsHuntsman Cancer Institute, University of Utah, Salt Lake City, 84112, UT, USA.
Bejal KikaniDepartment of Medicine, Division of Hematology, University of North Carolina, Chapel Hill, 27514, NC, USA.
Christopher E JensenDepartment of Medicine, Division of Hematology, University of North Carolina, Chapel Hill, 27514, NC, USA.
Douglas W SborovHuntsman Cancer Institute, University of Utah, Salt Lake City, 84112, UT, USA.
Deborah M StephensDepartment of Medicine, Division of Hematology, University of North Carolina, Chapel Hill, 27514, NC, USA.
Claire AcevedoDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, 92093, CA, USA.

Funding

Curing Through Collaboration: Utilizing Cooperative Groups in the Fight Against Chronic Lymphocytic Leukemia and B-cell LymphomasR50CA275929 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DEBORAH STEPHENS · 2023 to 2026
$673k
NCI NIH HHS R50 CA275929
6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is associated with increased fracture risk unexplained by standard bone density scans, suggesting underlying microstructural alterations. To investigate this, we used high-resolution synchrotron micro-computed tomography (SRμCT) on bone marrow biopsies from 17 CLL patients, who were stratified into low and high infiltration groups using objective, data-driven clustering. To our knowledge, this is the first report to quantify these changes. High CLL marrow infiltration was associated with a 40.3% reduction in lacuna density and a 101% increase in the normalized adipose surface area-to-volume ratio, a metric indicating greater structural fragmentation. Both changes correlated with leukemic infiltration percentage and showed partial reversal after therapy in a longitudinal case. Furthermore, high CLL burden significantly altered the morphological distributions of the remaining lacunar osteocyte (p < 0.001). We identify a novel marrow remodeling phenotype in CLL characterized by osteocyte depletion and adipose disruption. These changes likely contribute to skeletal fragility and represent potential microstructural biomarkers for assessing marrow health more accurately than conventional imaging.

Identifiers

PMID41279338
PMCPMC12633373

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.