ArticlebioRxiv : the preprint server for biology2025
A Reference Atlas of the Human Dorsal Root Ganglion.
Abstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Review
- Activating Transcription Factor 3 in Pain: A Molecular Regulator and Emerging Biomarker.Genes · 2026Review
- Semaphorins and Their Role in Neuropathic Pain.Life (Basel, Switzerland) · 2026Review
- Mapping the Extended Pain Pathway: Human Genetic and Multi-Omic Strategies for Next-Generation Analgesics.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
73 authors.
Shamsuddin A BhuiyanDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Saad S NagiDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Ishwarya SankaranarayananDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Evangelia SemizoglouDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Dmitry UsoskinDepartment of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden.
Lite YangWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Huasheng YuDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Asta Arendt-TranholmDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Zachariah BertelsWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Parth BhatiaDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Otmane BouchattaDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Kevin BoyerDepartment of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Anna CervantesSouthwest Transplant Alliance, Dallas, TX, USA.
Joshua ChalifDepartment of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Himanshu ChintalapudiDepartment of Neurology, Yale School of Medicine, Yale University, 100 College St, New Haven, CT, USA.
Anthony CicaloDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Bryan CopitsWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Caitlin CroninDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michele CuratoloDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Xianjun DongDepartment of Neurology, Yale School of Medicine, Yale University, 100 College St, New Haven, CT, USA.
Patrick M DoughertyDepartment of Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Adam DoursonWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Geoffrey FunkSouthwest Transplant Alliance, Dallas, TX, USA.
Katherin GabrielDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Dustin S GriesemerDepartment of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Hong GuoDepartment of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Prashant GuptaWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Christoph HofstetterDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Peter HortonSouthwest Transplant Alliance, Dallas, TX, USA.
Amanda HsiehDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nikhil Nageshwar InturiDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Aakanksha JainF.M. Kirby Neurobiology Center and Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Selwyn JayakarF.M. Kirby Neurobiology Center and Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Benjamin JohnstonDepartment of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Rebecca KimDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Doris KrauterDepartment of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden.
Jussi KupariDepartment of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden.
John LemenWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Joseph B LesnakDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Weiqiang LiuDepartment of Neurology, Yale School of Medicine, Yale University, 100 College St, New Haven, CT, USA.
Iris LopezDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Yi LuDepartment of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Hannah J MacMillanDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Khadijah MazharDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Pauline MeriauDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA.
Jeffrey R MoffittProgram in Cellular and Molecular Medicine and Department of Microbiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Marisol Mancilla MorenoDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Juliet M MwirigiWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Huma NazDepartment of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Jayden O'BreinDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Maria PayneWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
John Del RosarioWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Sarah F RosenDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA.
Stephanie ShiersDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Ebenezer SimpsonDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Richard SlivickiWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
James R StoneDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Diana Tavares-FerreiraDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Megan UhelskiDepartment of Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Clifford J WoolfF.M. Kirby Neurobiology Center and Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Qingru XuDepartment of Neurology, Yale School of Medicine, Yale University, 100 College St, New Haven, CT, USA.
Jiwon YiWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Muhammad Saad YousufDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Difei ZhuDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
Valeria CavalliDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA.
Guoyan ZhaoDepartment of Genetics and Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Håkan OlaussonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Patrik ErnforsDepartment of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden.
Robert W GereauWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Wenqin LuoDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Theodore J PriceDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
William RenthalDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School. Boston, MA, USA.
NIH PRECISION Human Pain Network
Funding
Spatial Core (Moffit)U19NS130617 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI William Russell Renthal · 2022 to 2026
$15.5MMulti-omics peripheral nerve atlas enables fine-mapping of pain molecular phenotypesU19NS130607 · NINDS · WASHINGTON UNIVERSITY · PI Sheng Chih Jin · 2022 to 2026
$14.0MMechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Michele Curatolo, Patrick M Dougherty · 2022 to 2026
$13.6MResearch Training for AnesthetistsT32GM007592 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI STUART A FORMAN · 1985 to 2026
$11.8MThe Penn Human Precision Pain Center (HPPC): Discovery and Functional Evaluation of Human Primary Somatosensory Neuron Types at Normal and Chronic Pain ConditionsU19NS135528 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Mingyao Li, Wenqin Luo · 2023 to 2026
$11.2MCentral and Peripheral Mechanisms of Corneal PainU01EY034709 · NEI · UNIVERSITY OF NEW ENGLAND · PI Pedram Hamrah, IAN D MENG · 2022 to 2026
$6.4MNext Generation Gene Therapy for Refractory PainR01NS119476 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI William Russell Renthal · 2022 to 2026
$3.4MEpigenomic labeling of cells that drive drug abuse behaviorDP1DA054343 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI RENTHAL, WILLIAM RUSSELL · 2021 to 2025
$2.7MNEI NIH HHS U01 EY034709NIDA NIH HHS DP1 DA054343NIGMS NIH HHS T32 GM007592NINDS NIH HHS R01 NS119476NINDS NIH HHS U19 NS130607NINDS NIH HHS U19 NS130608NINDS NIH HHS U19 NS130617NINDS NIH HHS U19 NS135528
Abstract
Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic pain and sensory loss. In mice, deep single-cell transcriptomic profiling and genetically defined models have offered important clues into DRG function, but in humans, the cellular and molecular landscape of DRG neurons remains less understood. Here, we constructed a reference cell atlas of the human DRG by profiling transcriptomes of cells and nuclei from 126 donors sampled across cervical, thoracic, and lumbar DRGs. This atlas resolves 22 neuronal subtypes, including known and previously unrecognized subtypes linked to nociception, mechanosensation, thermosensation, and proprioception, as well as 10 types of non-neuronal cells. Cross-species integration, spatial transcriptomics, and microneurography enabled cell-type-specific comparisons of soma size and conduction velocity between species. Human DRG somata are larger across all cell types than their mouse counterparts, and the conduction velocities of human hair follicle innervating A-fibers are faster than in mice, suggesting a functional shift in rapid mechanical detection in humans. This integrated human DRG reference cell atlas provides a resource for exploring new molecular and physiological features of human DRG, which could help identify new strategies for treating chronic pain and other diseases of the peripheral nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.