Evidence map›Paper›PMID 41279427›Full record

ArticlebioRxiv : the preprint server for biology2026

The Function of

Yue Peng, H Mark Kenney, Andriy Kobryn, Sean Lydon, Karen L de Mesy Bentley, Lianping Xing, Benjamin D Korman, Christopher T Ritchlin, Edward M Schwarz

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yue PengCenter for Musculoskeletal Research; University of Rochester Medical Center.ORCID 0000-0001-5524-4772
H Mark KenneyCenter for Musculoskeletal Research; University of Rochester Medical Center.
Andriy KobrynCenter for Musculoskeletal Research; University of Rochester Medical Center.
Sean LydonDepartment of Pathology & Laboratory Medicine; University of Rochester Medical Center.
Karen L de Mesy BentleyCenter for Musculoskeletal Research; University of Rochester Medical Center.
Lianping XingCenter for Musculoskeletal Research; University of Rochester Medical Center.ORCID 0000-0002-2588-7766
Benjamin D KormanCenter for Musculoskeletal Research; University of Rochester Medical Center.
Christopher T RitchlinCenter for Musculoskeletal Research; University of Rochester Medical Center.ORCID 0000-0002-2602-1219
Edward M SchwarzCenter for Musculoskeletal Research; University of Rochester Medical Center.ORCID 0000-0002-4854-9698

Funding

University of Rochester Mentoring Environment: Nurturing Training Opportunities in Research (UR-MENTOR)T32GM007356 · NIGMS · UNIVERSITY OF ROCHESTER · PI O'BANION, M. KERRY · 1985 to 2023
$15.1M
Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Elucidating the Mechanisms of Arthritic Flare and Developing TreatmentsR01AR056702 · NIAMS · UNIVERSITY OF ROCHESTER · PI SCHWARZ, EDWARD M. · 2009 to 2025
$4.9M
Synovial lymphatics and osteoarthritis in agingR01AG059775 · NIA · UNIVERSITY OF ROCHESTER · PI XING, LIANPING · 2020 to 2024
$1.9M
DC-STAMP: Regulator of Osteoclastogenesis and Response Marker in PsAR01AR069000 · NIAMS · UNIVERSITY OF ROCHESTER · PI RITCHLIN, CHRISTOPHER TREVOR · 2016 to 2020
$1.7M
Study of osteoblast regulation in TNF-mediated bone lossR01AR063650 · NIAMS · UNIVERSITY OF ROCHESTER · PI XING, LIANPING · 2013 to 2016
$1.4M
Elucidating the Mechanisms of Lymphatic Muscle Cell Dysfunction in Aging and InflammationF30AG076326 · NIA · UNIVERSITY OF ROCHESTER · PI KENNEY, HOWARD MARK · 2022 to 2023
$98k
NIAMS NIH HHS P30 AR069655NIAMS NIH HHS R01 AR056702NIAMS NIH HHS R01 AR063650NIAMS NIH HHS R01 AR069000NIA NIH HHS F30 AG076326NIA NIH HHS R01 AG059775NIGMS NIH HHS T32 GM007356
6 · The paper itself

Abstract

Resting collecting lymphatic vessels (cLVs) sense edema in distal joints and initiate contractions via unknown mechanisms. Rheumatoid arthritis (RA) patients have lymphatic drainage deficiencies from affected joints, and defects in the synovial lymphatic system exacerbate inflammatory-erosive arthritis in animal models. To understand this, we generated

Indexed as

Animal ModelsElectron MicroscopyInflammatory-Erosive ArthritisLymphatic VesselMast CellTelocyte

Identifiers

PMID41279427
PMCPMC12637515

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.