Evidence map›Paper›PMID 41279441›Full record

ArticlebioRxiv : the preprint server for biology2025

mRNA vaccination overcomes hemozoin-mediated impairment of whole parasite vaccine efficacy for malaria.

Mariah Hassert, Lisa L Drewry, Lecia L Pewe, Lisa S Hancox, Rui He, Sahaana Arumugam, Madison R Mix, Aliasger K Salem, John T Harty

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Mariah HassertDepartment of Pathology, University of Iowa-Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-2141-3344
Lisa L DrewryDepartment of Pathology, University of Iowa-Carver College of Medicine, Iowa City, IA, USA.
Lecia L PeweDepartment of Pathology, University of Iowa-Carver College of Medicine, Iowa City, IA, USA.
Lisa S HancoxDepartment of Pathology, University of Iowa-Carver College of Medicine, Iowa City, IA, USA.
Rui HeDepartment of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa-College of Pharmacy, Iowa City, IA, USA.
Sahaana ArumugamDepartment of Pathology, University of Iowa-Carver College of Medicine, Iowa City, IA, USA.
Madison R MixDepartment of Pathology, University of Iowa-Carver College of Medicine, Iowa City, IA, USA.
Aliasger K SalemDepartment of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa-College of Pharmacy, Iowa City, IA, USA.
John T HartyDepartment of Pathology, University of Iowa-Carver College of Medicine, Iowa City, IA, USA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Natoshia M. Askelson · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5M
Medical Scientist Training ProgramT32GM139776 · NIGMS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2021 to 2026
$6.4M
INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007260 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WU, LI · 1986 to 2023
$5.7M
Regulation of primary and secondary CD4 and CD8 T cell memoryR37AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2008 to 2017
$4.7M
Memory CD8 T cell localization and protection from influenzaR01AI114543 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, HARTY, JOHN T · 2015 to 2024
$4.4M
T resident memory in the lungR01AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 1998 to 2023
$4.4M
Understanding immune regulation in blood-stage malariaR01AI100527 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2012 to 2021
$3.6M
Immunity to Liver-stage malariaR01AI167847 · NIAID · UNIVERSITY OF IOWA · PI John T Harty · 2022 to 2026
$3.0M
Mechanisms of compromised CD8 T cell responses to vaccination in malaria experienced hostsR01AI185725 · NIAID · UNIVERSITY OF IOWA · PI John T Harty · 2024 to 2026
$2.3M
CST6-mRNA activated matrices for efficient bone regenerationR21DE031042 · NIDCR · UNIVERSITY OF IOWA · PI SALEM, ALIASGER K · 2022 to 2023
$425k
Cationic CAMKIIN nanoparticles that reduce chlorine-induced airway oxidative stressR21ES032937 · NIEHS · UNIVERSITY OF IOWA · PI SALEM, ALIASGER K · 2022 to 2023
$425k
NCI NIH HHS P30 CA086862NEI NIH HHS R21 EY034198NIAID NIH HHS F32 AI167088NIAID NIH HHS F32 AI174382NIAID NIH HHS K99 AI190129NIAID NIH HHS R01 AI042767NIAID NIH HHS R01 AI100527NIAID NIH HHS R01 AI114543NIAID NIH HHS R01 AI167847NIAID NIH HHS R01 AI185725NIAID NIH HHS R21 AI042767NIAID NIH HHS R37 AI042767NIAID NIH HHS T32 AI007260NIDCR NIH HHS R21 DE031042NIEHS NIH HHS P30 ES005605NIEHS NIH HHS R21 ES032937NIGMS NIH HHS T32 GM139776
6 · The paper itself

Abstract

Malaria is a persistent global public health threat. Immunization with Radiation Attenuated Sporozoites (RAS) drives efficient CD8+ T cell dependent sterilizing immunity to malaria in humans. However, this protection is compromised in individuals living in malaria endemic regions and the mechanism(s) of the vaccine failure remain incompletely understood. In this study, we develop a murine model of

Indexed as

hemozoinliver-stage malarialiver TRMmalariamRNA vaccineRAS vaccine

Identifiers

PMID41279441
PMCPMC12636498

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.