Evidence mapPaperPMID 41279447Full record

ArticlebioRxiv : the preprint server for biology2025

Co-targeting menin and LSD1 dismantles oncogenic programs and restores differentiation in MLL-rearranged AML.

Mina M Tayari, Helena Gomes Dos Santos, Felipe Beckedorff, Tulasigeri Totiger, Adnan Mookhtiar, Anna Lesley Kingham, Guilherme Miura Lavezzo, Gloria Mas Martin, Hsuan-Ting Huang, Efe Karaca and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mina M TayariSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Human Genetics, Miami, FL, United States.ORCID 0000-0003-3521-8782
Helena Gomes Dos SantosSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Human Genetics, Miami, FL, United States.ORCID 0000-0002-9671-4272
Felipe BeckedorffSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Human Genetics, Miami, FL, United States.ORCID 0000-0001-6735-6851
Tulasigeri TotigerSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Medicine, Miami, FL, United States.ORCID 0000-0002-4262-4458
Adnan MookhtiarSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Human Genetics, Miami, FL, United States.ORCID 0000-0002-5110-4518
Anna Lesley KinghamSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Medicine, Miami, FL, United States.
Guilherme Miura LavezzoSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Human Genetics, Miami, FL, United States.ORCID 0000-0002-8709-354X
Gloria Mas MartinSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Pathology and Laboratory Medicine, Cancer Modeling Shared Resource, Miami, FL, United States.ORCID 0000-0003-0730-3541
Hsuan-Ting HuangSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Pathology and Laboratory Medicine, Cancer Modeling Shared Resource, Miami, FL, United States.
Efe KaracaSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Pathology and Laboratory Medicine, Cancer Modeling Shared Resource, Miami, FL, United States.ORCID 0000-0003-4109-6013
Daniel BilbaoSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Pathology and Laboratory Medicine, Cancer Modeling Shared Resource, Miami, FL, United States.ORCID 0000-0003-1630-8811
Justin TaylorSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Medicine, Miami, FL, United States.ORCID 0000-0003-4407-6325
Ramin ShiekhattarSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Human Genetics, Miami, FL, United States.ORCID 0000-0002-7943-7277
Justin M WattsSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Department of Medicine, Miami, FL, United States.

Funding

Tumor Biology Research ProgramP30CA240139 · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2025 to 2025
$3.0M
Elucidation of Integrator's FunctionR01GM078455 · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2025 to 2025
$448k
NCI NIH HHS P30 CA240139NIGMS NIH HHS R01 GM078455
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) harboring

Indexed as

acute myeloid leukemia (AML)chromatin remodelingLEDGFLSD1 inhibitorMenin inhibitorMLL fusion

Identifiers

PMID41279447
PMCPMC12632788

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.