Evidence map›Paper›PMID 41279527›Full record

ArticlebioRxiv : the preprint server for biology2025

Disruption of a six-nucleotide miRNA motif improves

Ronak Lakhia, Chunzi Song, Laurence Biggers, Maggie Zumwalt, Jesus Alvarez, Arvind Somasundaram, Harini Ramalingam, Patricia Cobo-Stark, Vishal Patel

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ronak LakhiaDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas, USA 75390.
Chunzi SongDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas, USA 75390.
Laurence BiggersDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas, USA 75390.
Maggie ZumwaltDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas, USA 75390.
Jesus AlvarezDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas, USA 75390.
Arvind SomasundaramDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas, USA 75390.
Harini RamalingamDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas, USA 75390.
Patricia Cobo-StarkDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas, USA 75390.
Vishal PatelDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas, USA 75390.

Funding

The impact of RNA chemical modifications on polycystic kidney disease progressionR01DK102572 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI PATEL, VISHAL · 2015 to 2024
$3.5M
PKD1 derepression as a potential therapy for Polycystic Kidney DiseaseR01DK133186 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Vishal Patel · 2022 to 2026
$2.7M
Investigating intracellular cholesterol biosynthesis as a regulator of polycystic kidney disease progressionR01DK139033 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Ronak Lakhia · 2025 to 2026
$1.0M
NIDDK NIH HHS R01 DK102572NIDDK NIH HHS R01 DK133186NIDDK NIH HHS R01 DK139033
6 · The paper itself

Abstract

Disrupting microRNA interactions to restore protein expression from haploinsufficient genes offers a promising precision-therapy strategy for monogenic disorders.

Indexed as

3’-UTRADPKDmicroRNAmRNA TranslationOligonucleotidesPKD1

Identifiers

PMID41279527
PMCPMC12633239

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.