ArticlebioRxiv : the preprint server for biology2025
Structure-based engineering of a nutrient acquisition protein enhances neutralizing antibodies and protection for the development of a gonococcal vaccine.
Natalie Y T Au, En Ze L Zhong, Jamie E Fegan, Epshita A Islam, Stacey X Xu, Dixon Ng, Megha Shah, Laura-Lee Caruso, Christine C L Lai, Anthony B Schryvers and 2 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Natalie Y T AuDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.ORCID 0000-0003-2420-6559 En Ze L ZhongDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.ORCID 0000-0002-0373-8399 Jamie E FeganDepartment of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Epshita A IslamDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Stacey X XuDepartment of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Dixon NgDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Megha ShahDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Laura-Lee CarusoDepartment of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Christine C L LaiDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Anthony B SchryversDepartment of Microbiology, Immunology, and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.ORCID 0000-0002-4029-3296 Scott D Gray-OwenDepartment of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.ORCID 0000-0002-1477-3616 Trevor F MoraesDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.ORCID 0000-0001-9883-6145 Funding
Production of a Gonococcal Vaccine for Countering Antimicrobial ResistanceR01AI141229 · NIAID · UNIVERSITY OF CALGARY · PI GRAY-OWEN, SCOTT D, MORAES, TREVOR F · 2019 to 2024
$4.4MRational design of transferrin binding protein-based vaccines to combat gonorrheaR01AI125421 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CORNELISSEN, CYNTHIA N, GRAY-OWEN, SCOTT D · 2017 to 2021
$3.1MNIAID NIH HHS R01 AI125421NIAID NIH HHS R01 AI141229
6 · The paper itselfAbstract
Gonorrhea is increasingly resistant to treatment and has been labelled an urgent threat due to the diminishing effectiveness of existing therapeutics. To address this challenge, we targeted the
Indexed as
antigen designnutritional immunityTbpBtransferrinvaccine
Identifiers
PMID41279537
PMCPMC12637532
What Socratic holds
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