Evidence map›Paper›PMID 41279539›Full record

ArticlebioRxiv : the preprint server for biology2025

Single cell transcriptomics reveals enrichment of aggregation-prone alpha-synuclein isoforms across synucleinopathies.

E Keats Shwab, Webb Pierson, Daniel C Gingerich, Zhaohui Man, Sapir Margalit, Dean Yona, Asaf Sivan, Julia Gamache, Geidy E Serrano, Thomas G Beach and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

E Keats ShwabDivision of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, NC, 27710, USA.
Webb PiersonDivision of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, NC, 27710, USA.
Daniel C GingerichDivision of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, NC, 27710, USA.
Zhaohui ManDivision of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, NC, 27710, USA.
Sapir MargalitSchool of Chemistry, Tel-Aviv University, Tel-Aviv 6997801, Israel.
Dean YonaThe Center for Physics and Chemistry of Living Systems, Tel-Aviv University, Tel-Aviv 6997801, Israel.
Asaf SivanThe Center for Physics and Chemistry of Living Systems, Tel-Aviv University, Tel-Aviv 6997801, Israel.
Julia GamacheDivision of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, NC, 27710, USA.
Geidy E SerranoBanner Sun Health Research Institute, Sun City, Arizona, 85351, USA.ORCID 0000-0002-9527-2011
Thomas G BeachBanner Sun Health Research Institute, Sun City, Arizona, 85351, USA.
Yuval EbensteinSchool of Chemistry, Tel-Aviv University, Tel-Aviv 6997801, Israel.ORCID 0000-0002-7107-7529
Roy BeckThe Center for Physics and Chemistry of Living Systems, Tel-Aviv University, Tel-Aviv 6997801, Israel.
Ornit Chiba-FalekDivision of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, NC, 27710, USA.

Funding

CORE--NEUROPATHOLOGYP30AG019610 · SUN HEALTH RESEARCH INSTITUTE · 2001 to 2005
$4.7M
Research Education ComponentP30AG072980 · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2025 to 2025
$3.1M
Untangling the diversity in the genetic architecture of late-onset Alzheimer's disease using single cell multi-omicsRF1AG077695 · NIA · DUKE UNIVERSITY · PI Ornit Chiba-Falek · 2022 to 2022
$2.3M
NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028377NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG057522NIA NIH HHS RF1 AG077695NINDS NIH HHS RF1 NS113548NINDS NIH HHS U24 NS072026
6 · The paper itself

Abstract

Alpha-synuclein (α-Syn) is the primary component of Lewy bodies, the pathological hallmark of neurodegenerative synucleinopathies, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Dysregulated expression of its encoding gene,

Indexed as

Alpha-synucleinDementia with Lewy bodiesIsoformsLong-read sequencingParkinson’s diseaseProtein structureRNA splicingSingle-cell sequencingSynucleinopathiesTranscriptomics

Identifiers

PMID41279539
PMCPMC12632898

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.