Evidence map›Paper›PMID 41279558›Full record

ArticlebioRxiv : the preprint server for biology2025

State-dependent release of extracellular particles with distinct α2,6-sialylation patterns and small RNA cargo related to neuroinflammation.

Marta Garcia-Contreras, Carinna Lima, Eric Alsop, Balazs Kaszala, Bessie Meechoovet, Benjamin Purnell, Nan Jiang, Andras Saftics, Candice Tang, Olivia D Walsh and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marta Garcia-ContrerasCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8014-7966
Carinna LimaDepartment of Cancer Biology and Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.ORCID 0000-0003-4240-0400
Eric AlsopTranslational Genomics Research Institute, Phoenix, AZ, USA.ORCID 0000-0002-2717-7573
Balazs KaszalaCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Bessie MeechoovetTranslational Genomics Research Institute, Phoenix, AZ, USA.
Benjamin PurnellDepartment of Cancer Biology and Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.ORCID 0009-0000-4361-6743
Nan JiangDepartment of Cancer Biology and Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Andras SafticsDepartment of Cancer Biology and Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Candice TangDepartment of Cancer Biology and Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Olivia D WalshDepartment of Physics and Astronomy, California State Polytechnic University, Pomona, CA, USA.
Sophia HollandDepartment of Physics and Astronomy, California State Polytechnic University, Pomona, CA, USA.
Jimmy FayNanoFCM, ltd, Nottingham, UK.
Barbara SmithDepartment of Cell Biology, Johns Hopkins University, Baltimore, MD, USA.
Krishna P SigdelDepartment of Physics and Astronomy, California State Polytechnic University, Pomona, CA, USA.ORCID 0000-0001-7560-3285
Kendall Van Keuren-JensenTranslational Genomics Research Institute, Phoenix, AZ, USA.ORCID 0000-0001-8833-6323
Tijana Jovanovic-TalismanDepartment of Cancer Biology and Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.ORCID 0000-0003-1928-4763
Saumya DasCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4521-4606

Funding

Drug targeting the dynamics of opioid systems in alcohol dependenceR01AA028549 · NIAAA · KAROLINSKA INSTITUTE · PI MARTIN-FARDON, REMI, TALISMAN, TIJANA · 2020 to 2024
$2.6M
Molecular dissection and imaging of extracellular vesicles to define their origin and targetsUG3TR002878 · NCATS · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA, TALISMAN, TIJANA · 2019 to 2020
$939k
DIABETES PREVENTION / RISK / OMICS / METABOLISM / THERAPY (PROMT) INTERDISCIPLINARY TRAININGT32DK131943 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI RAMA NATARAJAN, Debbie C Thurmond · 2023 to 2026
$478k
NCATS NIH HHS UG3 TR002878NIAAA NIH HHS R01 AA028549NIDDK NIH HHS T32 DK131943
6 · The paper itself

Abstract

Neuroinflammation is a significant contributor to neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and related dementias; yet peripheral biomarkers for neuroinflammation remain an unmet medical need. Microglia, the resident immune cells of the central nervous system, play a dual role in maintaining homeostasis under physiological conditions and driving neuronal damage when chronically dysregulated. One mechanism by which microglia influence their environment is through the release of extracellular vesicles (EVs) and non-vesicular extracellular particles (NVEPs), which can serve as biomarkers the reflect cellular states. Here, we systematically isolated and characterized microglia-derived EVs and NVEPs under pro- and anti-inflammatory conditions and profiled their small RNA cargo by small RNA sequencing. We validated these findings in human iPSC-derived microglia and further recapitulated them in EVs and NVEPs from mouse brain and plasma. Using an engineered mouse model, we were able to isolate plasma microglia-specific EVs

Indexed as

exomeresExtracellular vesiclesmicrogliamiRNAneuroinflammationsupermeres

Identifiers

PMID41279558
PMCPMC12636399

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.