Evidence map›Paper›PMID 41279570›Full record

ArticlebioRxiv : the preprint server for biology2025

Multiplex design and discovery of proximity handles for programmable proteome editing.

Chase C Suiter, Green Ahn, Melodie Chiu, Yi Fu, Shayan Sadre, Jessica J Simon, David S Lee, Douglas M Fowler, Dustin J Maly, David Baker and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chase C SuiterMolecular and Cellular Biology Program, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3716-8275
Green AhnDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3086-4849
Melodie ChiuDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Yi FuDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0009-0004-5909-4475
Shayan SadreMolecular and Cellular Biology Program, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1047-984X
Jessica J SimonDepartment of Chemistry, Seattle, WA, USA.ORCID 0009-0006-5295-0608
David S LeeDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6539-4272
Douglas M FowlerDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7614-1713
Dustin J MalyDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0094-0177
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7896-6217
Jay ShendureMolecular and Cellular Biology Program, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1516-1865

Funding

Versatile, exponentially scalable methods for single cell molecular profilingR01HG010632 · NHGRI · UNIVERSITY OF WASHINGTON · PI Jay Ashok Shendure, Bruce Colston Trapnell · 2019 to 2026
$5.9M
Training in Cellular & Molecular BiologyT32GM136534 · NIGMS · UNIVERSITY OF WASHINGTON · PI Andrew Atwell Oberst, LARRY S ZWEIFEL · 2021 to 2026
$5.8M
Comprehensive identification of E3 ubiquitin ligases that degrade heart, lung, and blood-relevant transcription factorsF31HL168982 · NHLBI · UNIVERSITY OF WASHINGTON · PI SUITER, CHASE CAMERON · 2023 to 2024
$86k
NHGRI NIH HHS R01 HG010632NHLBI NIH HHS F31 HL168982NIGMS NIH HHS T32 GM136534
6 · The paper itself

Abstract

Although we now have a rich toolset for genome editing, an equivalent framework for manipulating the proteome with a comparable flexibility and specificity remains elusive. A promising strategy for "proteome editing" is to use bifunctional molecules (

Identifiers

PMID41279570
PMCPMC12632987

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.