Evidence map›Paper›PMID 41279590›Full record

ArticlebioRxiv : the preprint server for biology2025

Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in

Fu-Hsuan Ko, Amanda K Lukens, Mariana Laureano de Souza, Alex Foy, Jason Hsiao, Tolla Ndiaye, John Okombo, Tomas Yeo, Heekuk Park, Anne-Catrin Uhlemann and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Fu-Hsuan KoDivision of Biological Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-8939-7387
Amanda K LukensInfectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA USA.
Mariana Laureano de SouzaDepartment of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA USA.
Alex FoyDepartment of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA USA.
Jason HsiaoDivision of Biological Sciences, University of California San Diego, La Jolla, CA, USA.
Tolla NdiayeDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
John OkomboDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Tomas YeoDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Heekuk ParkDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Anne-Catrin UhlemannDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Nonlawat BoonyalaiBiological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.
Krittikorn KumpornsinWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire UK.
Gareth GirlingWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire UK.
Charisse PasajeDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA.
Luiz GodoyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA.
Sabine OttilieDepartment of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA USA.
Gregory L DurstLgenia Inc., Fortville, IN 46040, USA.
Arnab ChatterjeeScripps Research Institute, La Jolla, CA 92037, USA.
Jacquin NilesDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA.
Marcus LeeBiological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.
David A FidockDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Dyann F WirthInfectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA USA.
Elizabeth A WinzelerDepartment of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA USA.ORCID 0000-0002-4049-2113

Funding

Defining the resistome in P. falciparum: evolution and mechanismR01AI169892 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Daniel E. Goldberg, Elizabeth A Winzeler · 2023 to 2026
$4.4M
Discovery of long-acting, chemoprotective antimalarial compoundsR01AI152533 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2020 to 2024
$3.5M
Defining the complex genetic basis of Plasmodium falciparum resistance to artemisinin and quinine and identifying resistance-refractory therapeuticsR01AI185559 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2024 to 2026
$1.9M
Gates Foundation INV-033538NIAID NIH HHS R01 AI152533NIAID NIH HHS R01 AI169892NIAID NIH HHS R01 AI185559
6 · The paper itself

Abstract

Drug resistance is a widespread problem across therapeutic areas including malaria, but what accounts for resistance propensity remains poorly understood. Here, we reveal that two HSP90 inhibitors targeting the identical ATP-binding site exhibit dramatically different resistance profiles in

Identifiers

PMID41279590
PMCPMC12636505

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.