Evidence map›Paper›PMID 41279636›Full record

ArticlebioRxiv : the preprint server for biology2025

Engineering a Biomimetic Multiphasic Suture Anchor System for Enhanced Rotator Cuff Enthesis Regeneration.

Zizhao Li, Se-Hwan Lee, Lin Xu, Marina Santos, Ruqiang Lu, Ellen Y Zhang, DongHwa Kim, Bat-Ider Tumenbayar, Tyler Blanch, Jaeun Jung and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Zizhao LiMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA, 19104, United States.
Se-Hwan LeeMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA, 19104, United States.
Lin XuMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA, 19104, United States.
Marina SantosNew Bolton Center, Department of Clinical Studies, University of Pennsylvania, 382 West Street Road Kennett Square, Philadelphia, PA, 19348, United States.
Ruqiang LuAcuitive Technologies, Inc., 50 Commerce Drive, Allendale, NJ, 07401, United States.
Ellen Y ZhangMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA, 19104, United States.
DongHwa KimMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA, 19104, United States.
Bat-Ider TumenbayarMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA, 19104, United States.
Tyler BlanchMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA, 19104, United States.
Jaeun JungMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA, 19104, United States.
Jayden ShinMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA, 19104, United States.
Yongho BaeDepartment of Pathology and Anatomical Sciences and Department of Biomedical, Engineering, University at Buffalo, 955 Main Street, Buffalo, NY, 14203, United States.ORCID 0000-0002-1838-1652
Richard T TranAcuitive Technologies, Inc., 50 Commerce Drive, Allendale, NJ, 07401, United States.
Thomas SchaerNew Bolton Center, Department of Clinical Studies, University of Pennsylvania, 382 West Street Road Kennett Square, Philadelphia, PA, 19348, United States.
Su Chin HeoMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA, 19104, United States.ORCID 0000-0003-2771-5076

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and PathologyR01HL163168 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Yongho Bae, Su Chin Heo · 2023 to 2026
$2.2M
NHLBI NIH HHS R01 HL163168NIAMS NIH HHS P30 AR069619
6 · The paper itself

Abstract

Conventional suture anchor methods in rotator cuff repair often fail to replicate the native tendon-to-bone interface, leading to re-tears due to stress concentrations and poor biological integration at anchor sites. To address these challenges, we engineered a biomimetic multiphasic scaffold system (BMS) that integrates with standard suture anchors and deliver spatially organized structural and biological cues to enhance enthesis regeneration. The BMS comprises three distinct phases: aligned nanofibrous decellularized bovine Achilles tendon extracellular matrix (dECM) with 'stiff' methacrylated hyaluronic acid (MeHA) for tendon regeneration; nonaligned nanofibrous dECM with 'soft' MeHA for fibrocartilage formation; and a porous, citrate-based composite scaffold with bioactive glass for bone integration.

Indexed as

citrate-based polymerEnthesis RegenerationMultiphasic scaffoldRotator Cuff RepairTunable decellularized extracellular matrix

Identifiers

PMID41279636
PMCPMC12636334

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.