Evidence map›Paper›PMID 41279668›Full record

ArticlebioRxiv : the preprint server for biology2025

Disease modulation by TIV vaccination during secondary pneumococcal infections in influenza-infected mice.

Juan García-Bernalt Diego, Javier Arranz-Herrero, Gabriel Laghlali, Eleanor Burgess, Seok-Chan Park, Gagandeep Singh, Lauren A Chang, Prajakta Warang, Moataz Noureddine, Jordi Ochando and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Juan García-Bernalt DiegoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York New York.
Javier Arranz-HerreroTransplant Immunology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid Spain.
Gabriel LaghlaliDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York New York.
Eleanor BurgessDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York New York.
Seok-Chan ParkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York New York.
Gagandeep SinghDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York New York.
Lauren A ChangDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York New York.ORCID 0000-0002-3287-3987
Prajakta WarangDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York New York.
Moataz NoureddineDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York New York.
Jordi OchandoDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York New York.
Estanislao Nistal-VillanMicrobiology Section, Dpto. CC, Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, 28668, Madrid, Spain.ORCID 0000-0003-2458-8833
Michael SchotsaertDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York New York.ORCID 0000-0003-3156-3132

Funding

COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
Adjuvant strategies for universal and multiseasonal influenza vaccine candidates in the context of pre-existing immunityR21AI176069 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHOTSAERT, MICHAEL, WONG, PAMELA TINMOI · 2023 to 2024
$466k
A Miniature Pig Model for the Study of Host-Immune Responses Against Influenza A VirusR21AI151229 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RICHT, JUERGEN A, SCHOTSAERT, MICHAEL · 2020 to 2021
$457k
NIAID NIH HHS 75N93019C00051NIAID NIH HHS 75N93021C00014NIAID NIH HHS R21 AI151229NIAID NIH HHS R21 AI176069
6 · The paper itself

Abstract

Secondary bacterial infections can significantly worsen the clinical course of influenza virus infections and are a leading cause of morbidity and mortality during seasonal influenza epidemics. Despite being a vaccine-preventable disease, influenza-related complications from secondary bacterial infections are an important cause of death, particularly among the elderly population.

Indexed as

bacterial coinfectionbacterial superinfectioninfluenza virusStreptococcus pneumoniaeTIV

Identifiers

PMID41279668
PMCPMC12632982

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.