Evidence map›Paper›PMID 41279762›Full record

ArticlebioRxiv : the preprint server for biology2025

WSB.

Kristen D Onos, Olivia J Marola, Asli Uyar, Kelly J Keezer, Juan Antonio K Chong Chie, Kevin Elk, Phillip Bohn, Abigail E Cullen, Kierra Eldridge, Scott Persohn and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Kristen D OnosThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Olivia J MarolaThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Asli UyarThe Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.
Kelly J KeezerThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Juan Antonio K Chong ChieStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0003-3111-2294
Kevin ElkThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Phillip BohnAllen Institute or Brain Science, Seattle, WA, 98109, USA.
Abigail E CullenDepartment of Human Physiology, University of Oregon, Eugene, Oregon, 97403, USA.
Kierra EldridgeStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Scott PersohnStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Jonathan Nyandu KanyindaThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Heidi K KocalisThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Jennifer D WhitesellAllen Institute or Brain Science, Seattle, WA, 98109, USA.
Julie A HarrisAllen Institute or Brain Science, Seattle, WA, 98109, USA.
Paul SalamaDepartment of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Ashley E WalkerDepartment of Human Physiology, University of Oregon, Eugene, Oregon, 97403, USA.
Gregory CarterThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.ORCID 0000-0002-2834-8186
Michael SasnerThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Paul R TerritoStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Gareth R HowellThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.ORCID 0000-0003-0565-6474

Funding

The IU/JAX Alzheimer's Disease Precision Models Center: Rat F344U54AG054345 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Gareth R Howell · 2016 to 2026
$95.6M
UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2017 to 2026
$71.9M
Modulation of TNFα as a Treatment for Alzheimer's Disease and Related DementiaR21AG078575 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI HOWELL, GARETH R, TERRITO, PAUL RICHARD · 2022 to 2022
$469k
NIA NIH HHS R21 AG078575NIA NIH HHS U54 AG054345NIA NIH HHS U54 AG054349
6 · The paper itself

Abstract

Vascular contributions are now widely accepted to play a key role in many cases of dementia, including Alzheimer's disease (AD), that commonly manifest as cerebral small vessel diseases, including cerebral amyloid angiopathy (CAA). However, the mechanisms by which vascular contributions such as CAA contribute dementias such as AD are not well understood. This is due in part to the lack mouse models that develop robust CAA, hampering our ability to develop therapies that target vascular deficits. To address this, we have explored the use of distinct genetic contexts to enhance the face validity of mouse models for AD. We have previously identified the WSB/EiJ (WSB) strain as a model that shows increased susceptibility to CAA in the presence of the

Indexed as

Alzheimer’s disease and related dementiascerebral amyloid angiopathyvascular deficitsWSB

Identifiers

PMID41279762
PMCPMC12632456

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.