Evidence map›Paper›PMID 41279770›Full record

ArticlebioRxiv : the preprint server for biology2025

Longitudinal Imaging of the Premalignant Tumor Microenvironment Reveals Transient Myeloid States Predictive of Tumor Fate.

Thomas D Madsen, Desu Chen, Maria Hernandez, Sarah Hammoudeh, Marco Heydecker, Emily Chen, Salma Abu-Elnaj, Noemi Kedei, Weiye Wang, Roberto Weigert

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thomas D MadsenLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Desu ChenLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Maria HernandezSpatial Imaging Technology Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sarah HammoudehLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Marco HeydeckerLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Emily ChenLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Salma Abu-ElnajLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Noemi KedeiSpatial Imaging Technology Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Weiye WangLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Roberto WeigertLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0740-4465

Funding

Molecular mechanisms of membrane remodelingZIABC011682 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WEIGERT, ROBERTO · 2016 to 2025
$17.5M
Intramural NIH HHS ZIA BC011682
6 · The paper itself

Abstract

The spontaneous regression of cancer lesions demonstrates the potential of immune surveillance; yet, these transient events have remained inaccessible to systematic study. Using longitudinal intravital microscopy in a carcinogen-induced model of head and neck cancer, we tracked premalignant lesions within the same animals for 24 weeks at single-cell resolution. This approach revealed three trajectories: progression, stability, or regression, and enabled dissection of the immune dynamics underlying each fate. Lesion outcome was dictated by the spatial organization of myeloid-derived antigen-presenting cells: regressing lesions were characterized by dense clusters of myeloid-derived cells associated with CXCL9

Indexed as

Cxcl10Cxcl9Immune checkpoint inhibitorIntravital microscopyM2 macrophageMyeloid NichePremalignant lesionsSpontaneous regressionTumor-Associated MacrophageTumor metabolismTumor microenvironment

Identifiers

PMID41279770
PMCPMC12637611

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.