Evidence map›Paper›PMID 41279878›Full record

ArticlebioRxiv : the preprint server for biology2025

NADH dehydrogenase reverses dietary and clock metabolic syndrome.

Chelsea Hepler, Nathan J Waldeck, Benjamin J Weidemann, Biliana Marcheva, You-Jia Chen, Jacqueline Hecker, Ziming Zhu, Rino Nozawa, Joseph V Mastroni, Anneke K Thorne and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Chelsea HeplerDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Nathan J WaldeckDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Benjamin J WeidemannDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Biliana MarchevaDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
You-Jia ChenDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Jacqueline HeckerDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Ziming ZhuDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Rino NozawaDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Joseph V MastroniDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Anneke K ThorneDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Colleen R ReczekDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL 60611, USA.
Jonathan CedernaesDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Kathryn M RamseyDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Clara B PeekDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Grant D BarishDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Navdeep S ChandelDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL 60611, USA.
Joseph BassDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
SLOW WAVE SLEEP AND TYPE 2 DIABETES RISK IN AGINGP01AG011412 · NIA · UNIVERSITY OF CHICAGO · PI ZEE, PHYLLIS C. · 1994 to 2021
$31.5M
Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2003 to 2019
$30.8M
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAVDEEP S CHANDEL · 2015 to 2026
$26.9M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI RONALD N COHEN · 2013 to 2026
$20.9M
Training Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6M
TRAINING GRANT IN SLEEP RESEARCHT32HL007909 · NHLBI · NORTHWESTERN UNIVERSITY · PI FRED W TUREK, Phyllis C. Zee · 1998 to 2026
$9.2M
Integration of Feeding Time and Glucose Metabolism by the Circadian Gene NetworkR01DK090625 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH, LERNER, TALIA NEWCOMBE · 2011 to 2025
$6.9M
Mitochondrial metabolism and ROS regulate cancerR35CA197532 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2016 to 2022
$6.3M
Nuclear Repressors in Genomic Control of Healthful ObesityR01DK108987 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BARISH, GRANT D · 2016 to 2024
$3.4M
Clock Control of Muscle Glucose Metabolism and HIF ActivityR01DK123358 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Clara Bien Peek · 2020 to 2026
$2.4M
Cross-regulation of Immunometabolism and Circadian Pathways in Obesity PathophysiologyR01DK127800 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2021 to 2025
$2.3M
BLRD VA I01 BX004898NCI NIH HHS P30 CA060553NCI NIH HHS R35 CA197532NHLBI NIH HHS P01 HL071643NHLBI NIH HHS T32 HL007909NHLBI NIH HHS T32 HL076139NIA NIH HHS P01 AG011412NIA NIH HHS P01 AG049665NIA NIH HHS R01 AG065988NIDDK NIH HHS F30 DK116481NIDDK NIH HHS F31 DK130589NIDDK NIH HHS F32 DK122675NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK090625NIDDK NIH HHS R01 DK108987NIDDK NIH HHS R01 DK113011NIDDK NIH HHS R01 DK123358NIDDK NIH HHS R01 DK127800NIDDK NIH HHS R01 DK132647NIH HHS S10 OD025120
6 · The paper itself

Abstract

Circadian clocks are internal timing systems that enable organisms to anticipate and adapt to daily environmental changes. These rhythms arise from a transcription-translation feedback loop in which CLOCK/BMAL1 regulate the expression of thousands of genes, including their repressors PER/CRY

Indexed as

adipocytesBMAL1Circadian clockcomplex ImetabolismmitochondriaNDI1

Identifiers

PMID41279878
PMCPMC12633269

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.