Evidence map›Paper›PMID 41279989›Full record

ArticlebioRxiv : the preprint server for biology2025

Ivermectin Reduces Withdrawal-Induced Alcohol Intake via CeA GABAergic Enhancement.

Paola Campo, Ran Qiao, Michelle R Doyle, Daniel Munro, Benjamin J Johnson, Abraham A Palmer, Marsida Kallupi, Giordano de Guglielmo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Paola CampoDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093.ORCID 0009-0002-6969-7427
Ran QiaoDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093.
Michelle R DoyleDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093.
Daniel MunroDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093.
Benjamin J JohnsonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093.ORCID 0000-0001-7269-5145
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093.ORCID 0000-0003-3634-0747
Marsida KallupiDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093.
Giordano de GuglielmoDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093.ORCID 0000-0002-4782-7430

Funding

Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
DP30DA060810 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Oksana O Polesskaya · 2024 to 2026
$5.6M
A Framework for Translating Polygenic Findings Related to Alcohol Use Disorder Across SpeciesR01AA029688 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hae Kyung Im, Abraham A Palmer · 2022 to 2026
$3.1M
Identification of Genetic Variants that Influence Compulsive Alcohol Intake in Outbred RatsR01AA030048 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Giordano De Guglielmo · 2023 to 2026
$1.7M
NIAAA NIH HHS R01 AA029688NIAAA NIH HHS R01 AA030048NIAAA NIH HHS T32 AA007456NIDA NIH HHS P30 DA060810
6 · The paper itself

Abstract

Although FDA-approved medications for alcohol use disorder (AUD) are available, their efficacy varies across patients, highlighting the need for novel therapeutics that address interindividual differences in disease etiology and treatment response. Genetic models, particularly heterogeneous stock (HS) rats, recapitulate human-like genetic diversity and behavioral heterogeneity, enabling the dissection of individual differences in vulnerability to AUD and pharmacotherapeutic sensitivity. P2X4 receptors, which are encoded by the gene

Indexed as

Alcohol Use Disorder (AUD)Chronic Intermittent Ethanol (CIE)GABAergic InhibitionHeterogeneous Stock (HS) RatsIvermectinP2X4 Receptors

Identifiers

PMID41279989
PMCPMC12632938

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.