Evidence map›Paper›PMID 41280062›Full record

ArticlebioRxiv : the preprint server for biology2025

A biphasic metabolism-β-lactamase production landscape governs the inoculum effect in β-lactamase-expressing

Ariane R Kalifa Torjeman, Kielan Singh, Philopatier Ibrahim, Trent Moulder, Naziba Nuha, Julia Gumirov, Tiffany Rakela, Debora Pereira Mcmenamin, Daniel Winget, Taija White and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ariane R Kalifa TorjemanCell Therapy Institute, Kiran Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, 33314.
Kielan SinghDepartment of Biological Sciences, Halmos College of Arts and Sciences, Nova Southeastern University, Fort Lauderdale, FL, 33314.
Philopatier IbrahimDepartment of Biological Sciences, Halmos College of Arts and Sciences, Nova Southeastern University, Fort Lauderdale, FL, 33314.
Trent MoulderDepartment of Biological Sciences, Halmos College of Arts and Sciences, Nova Southeastern University, Fort Lauderdale, FL, 33314.
Naziba NuhaDepartment of Biological Sciences, Halmos College of Arts and Sciences, Nova Southeastern University, Fort Lauderdale, FL, 33314.
Julia GumirovDepartment of Biological Sciences, Halmos College of Arts and Sciences, Nova Southeastern University, Fort Lauderdale, FL, 33314.
Tiffany RakelaCell Therapy Institute, Kiran Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, 33314.
Debora Pereira McmenaminCell Therapy Institute, Kiran Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, 33314.
Daniel WingetDepartment of Medical Education, Kiran Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, 33314.
Taija WhiteDepartment of Medical Education, Kiran Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, 33314.
Archit PipalvaDepartment of Medical Education, Kiran Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, 33314.
Allison J LopatkinDepartment of Chemical Engineering, University of Rochester; Rochester, NY 14627; USA.ORCID 0000-0003-0018-9205
Robert P SmithCell Therapy Institute, Kiran Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, 33314.ORCID 0000-0003-2744-7390

Funding

Determinants underlying horizontal gene transfer-mediated pathogen successR35GM150871 · NIGMS · UNIVERSITY OF ROCHESTER · PI Allison Lopatkin · 2023 to 2026
$1.7M
Does growth efficiency determine the inoculum effect?R15AI159902 · NIAID · NOVA SOUTHEASTERN UNIVERSITY · PI SMITH, ROBERT P · 2022 to 2022
$462k
NIAID NIH HHS R15 AI159902NIGMS NIH HHS R35 GM150871
6 · The paper itself

Abstract

The inoculum effect (IE) reduces the efficacy of antibiotics both

Indexed as

density-dependentgrowth rateinoculum effectmetabolismβ-lactamβ-lactamase

Identifiers

PMID41280062
PMCPMC12633061

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.