Evidence map›Paper›PMID 41280119›Full record

ArticlebioRxiv : the preprint server for biology2025

Expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and late postnatal development.

Jennifer Armstrong, Katherine Griffiths, Newton Martin, Estefania Oneil, Santina Temi, Annemarie Dedek, Jessica Parnell, Christopher Rudyk, Julia Bursey, Jeffrey L Krajewski and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Jennifer ArmstrongDepartment of Neuroscience, Carleton University, Ontario, Canada.
Katherine GriffithsDepartment of Neuroscience, Carleton University, Ontario, Canada.ORCID 0009-0005-9608-3895
Newton MartinDepartment of Neuroscience, Carleton University, Ontario, Canada.
Estefania OneilLilly Research Laboratories, Indianapolis, Indiana, United States.
Santina TemiDepartment of Neuroscience, Carleton University, Ontario, Canada.
Annemarie DedekDepartment of Neuroscience, Carleton University, Ontario, Canada.
Jessica ParnellDepartment of Neuroscience, Carleton University, Ontario, Canada.
Christopher RudykDepartment of Neuroscience, Carleton University, Ontario, Canada.
Julia BurseyDepartment of Neuroscience, Carleton University, Ontario, Canada.
Jeffrey L KrajewskiLilly Research Laboratories, Indianapolis, Indiana, United States.
Jeff S McDermottLilly Research Laboratories, Indianapolis, Indiana, United States.
Ariel J LevineSpinal Circuits and Plasticity Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States.
Baolin LiLilly Research Laboratories, Indianapolis, Indiana, United States.
Eve C TsaiNeuroscience Program, Ottawa Hospital Research Institute, Ontario, Canada.
Michael E HildebrandDepartment of Neuroscience, Carleton University, Ontario, Canada.

Funding

Mechanisms of Plasticity in the Spinal CordZIANS003153 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LEVINE, ARIEL · 2016 to 2025
$20.9M
Intramural NIH HHS ZIA NS003153
6 · The paper itself

Abstract

Despite being essential mediators of pain processing, the molecular identity of N-methyl-D-aspartate receptor (NMDAR) subtypes in nociceptive dorsal horn circuits is poorly understood, especially between sexes and in humans. Given the importance of GluN2 subunits in shaping NMDAR function and plasticity, we investigated the expression and localization of specific GluN2 NMDAR variants in the dorsal horn of viable spinal cord tissue from male and female rodents and human organ donors. Analysis of single-cell/nuclei sequencing datasets revealed that the GluN2A (

Identifiers

PMID41280119
PMCPMC12633401

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.