ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Blood Pressure Levels During Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study and Mendelian Randomization Analysis.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Dose-response relationship between early pregnancy blood pressure and gestational diabetes mellitus based on propensity score matching: a retrospective study.BMC pregnancy and childbirth · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: We aimed to investigate the association and causality between blood pressure (BP) during pregnancy and gestational diabetes mellitus (GDM). Methods: In a Chinese birth cohort study, 5,952 participants with repeated measurements of BP were included. Logistic regression models were used to estimate the associations between BP and BP trajectories with the risk of GDM. Polygenic risk scores (PRS) were used in a one-sample Mendelian randomization (MR) analysis conducted on a subset of the cohort. Linkage disequilibrium score regression and a two-sample MR analysis were performed to explore genetic correlation and causal relationship between BP and GDM in both Europeans and East Asians. Results: Elevated first and mean systolic blood pressure (SBP) during pregnancy were both associated with an increased risk of GDM. Individuals with a High-stable SBP trajectory throughout pregnancy had a higher risk of GDM (OR, 1.43[95% CI, 1.07-1.88]) compared to those with a low-stable SBP trajectory. The top quintile of genetically predicted SBP was associated with an increased risk of GDM compared to the lowest quintile (OR, 1.54[95% CI, 1.05-2.27]). A modest genetic correlation between SBP and GDM was observed in Europeans ( Conclusion: Our findings highlight the crucial role of elevated SBP in the development of GDM. Further genetic correlation and MR studies provide compelling evidence suggesting a potential causal relationship, thereby enhancing our understanding of the etiology of GDM.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.