Evidence map›Paper›PMID 41280390›Full record

ArticleFrontiers in nutrition2025

Exploring the molecular mechanism of EGCG in preventing obesity-induced precocious puberty based on serum metabolomics and molecular docking.

Shiyu Gao, Lina Xia, Chenzhenghao Jiang, Bang Shao, Ying Shao, Xiaojing Li, Peiying Wu, Jieyi He, Qiujv Du, Lingwei Liang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shiyu Gao *Department of Nutrition, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lina Xia *Department of Nutrition, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chenzhenghao JiangDepartment of Nutrition, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bang ShaoDepartment of Nutrition, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying ShaoDepartment of Nutrition, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaojing LiDepartment of Pharmacy, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.
Peiying WuDepartment of Nutrition, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jieyi HeDepartment of Nutrition, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qiujv DuDepartment of Nutrition, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lingwei LiangDepartment of Nutrition, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qiuyun GuDepartment of Nutrition, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Obesity-induced precocious puberty presents serious health risks to adolescents. Building on our previous finding that epigallocatechin gallate (EGCG) exhibits a preventive effect on obesity-induced precocious puberty, the present study aims to elucidate the underlying molecular mechanisms. Methods: Female C57BL/6 mice were divided into four groups: control, normal diet + EGCG, high-fat diet (HFD), and HFD + EGCG. Body weight, vaginal opening time, and serum samples were analyzed to assess the effects of EGCG on obesity-induced precocious puberty, using serum metabolomics and molecular docking. Results: EGCG treatment significantly altered the serum metabolite profile, particularly affecting lipid metabolism. Glycerophospholipid metabolism emerged as the key pathway modulated by EGCG. Molecular docking identified phosphatidylserine decarboxylase, phospholipase D, and phosphatidylserine synthase as potential targets. Conclusion: EGCG prevents obesity-induced precocious puberty, an effect associated with the reshaping of lipid metabolism, with key enzymes in the glycerophospholipid metabolism serving as potential therapeutic targets. These findings provide a foundational hypothesis for further mechanistic investigation.

Indexed as

differential metabolitesepigallocatechin gallatemolecular dockingobesity-induced precocious pubertyserum metabolomics

Identifiers

PMID41280390
PMCPMC12631206

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.