Evidence map›Paper›PMID 41280563›Full record

ArticleAmerican journal of nuclear medicine and molecular imaging2025

Radiosynthesis and evaluation of an

Jian Rong, Chunyu Zhao, Ahmad F Chaudhary, Jiahui Chen, Yinlong Li, Xin Zhou, Zhendong Song, Zhenkun Sun, Yabiao Gao, Siyan Feng and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jian RongDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Chunyu ZhaoDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Ahmad F ChaudharyDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Jiahui ChenDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Yinlong LiDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Xin ZhouDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Zhendong SongDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Zhenkun SunDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine Atlanta, Georgia 30322, The United States.
Yabiao GaoDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Siyan FengDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Taoqian ZhaoDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Qi-Long HuDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Chongjiao LiDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Achi HaiderDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Jimmy PatelDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
Chongzhao RanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts 02114, The United States.
Hongjie YuanDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine Atlanta, Georgia 30322, The United States.
Steven H LiangDepartment of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.

Funding

Subtype-Selective Metabotropic Glutamate Receptor PET LigandsR61NS130128 · NINDS · EMORY UNIVERSITY · PI Steven H Liang · 2023 to 2026
$2.4M
micro-PET/CT system for preclinical molecular imagingS10OD034326 · OD · EMORY UNIVERSITY · PI LIANG, STEVEN H · 2024 to 2024
$600k
NIH HHS S10 OD034326NINDS NIH HHS R61 NS130128
6 · The paper itself

Abstract

The metabotropic glutamate receptor 3 (mGluR3) is a G-protein-coupled receptor (GPCR) involved in modulating glutamatergic neurotransmission and maintaining neural homeostasis. By inhibiting adenylyl cyclase activity, mGluR3 negatively modulates the activity of adenylyl cyclase via Gi/o protein coupling, reducing cyclic AMP (cAMP) levels and modulating downstream signaling pathways. Dysfunction of mGluR3 is associated with a range of neurological and psychiatric disorders, including depression, autism, cognitive impairment, bipolar affective disorder, schizophrenia, and neurodegenerative diseases. Despite its therapeutic relevance, no selective mGluR3 positron emission tomography (PET) radioligand is currently available to image this target

Indexed as

fluorine-18Metabotropic glutamate receptor 3mGluR3negative allosteric modulatorpositron emission tomography

Identifiers

PMID41280563
PMCPMC12629903

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.