Evidence map›Paper›PMID 41280678›Full record

ArticleiScience2025

Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling.

Laura Schwartz, Kristin Salamon, Aaron Simoni, Israel Cotzomi-Ortega, Yuriko Sanchez-Zamora, Sarah Linn-Peirano, Preeti John, Juan de Dios Ruiz-Rosado, Ashley R Jackson, Xin Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Laura SchwartzThe Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, OH, USA.
Kristin SalamonThe Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, OH, USA.
Aaron SimoniThe Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, OH, USA.
Israel Cotzomi-OrtegaThe Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, OH, USA.
Yuriko Sanchez-ZamoraThe Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, OH, USA.
Sarah Linn-PeiranoThe Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, OH, USA.
Preeti JohnThe Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, OH, USA.
Juan de Dios Ruiz-RosadoThe Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, OH, USA.
Ashley R JacksonThe Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, OH, USA.
Xin WangThe Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, OH, USA.
John David SpencerThe Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, OH, USA.

Funding

Transgenic AnimalP30CA016058 · NCI · OHIO STATE UNIVERSITY · 1985 to 2025
$46.0M
Insulin Signaling Activates Urothelial Defenses to Reduce Urinary Tract Infection SusceptibilityR01DK128088 · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2025 to 2025
$511k
NCI NIH HHS P30 CA016058NIDDK NIH HHS R01 DK114035NIDDK NIH HHS R01 DK128088
6 · The paper itself

Abstract

Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse model in male and female C57BL/6 mice, we show that high-fat diet feeding heightens vulnerability to uropathogenic

Indexed as

Biological sciencesCell biologyModel organismTranscriptomics

Identifiers

PMID41280678
PMCPMC12637249

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.