Evidence map›Paper›PMID 41280680›Full record

ArticleiScience2025

Single mutation tunes IRF4 function and mediates B cell character to ameliorate murine lupus.

Ze Xiu Xiao, Rongzhen Liang, Xiaojiang Hu, Changyuan Huang, Jia Nie, Chichu Xie, Julie Wang, Qiannan Fang, Xiaoli Fan, Nancy Olsen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ze Xiu XiaoDivision of Rheumatology and Immunology, Department of Immunology, the School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Rongzhen LiangDivision of Rheumatology and Immunology, Department of Immunology, the School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Xiaojiang HuDepartment of Clinical Immunology, the Third Affiliated Hospital at the Sun Yat-sen University, Guangzhou 510630, China.
Changyuan HuangDepartment of Immunology, the First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan 523000, China.
Jia NieDepartment of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Chichu XieDepartment of Clinical Immunology, the Third Affiliated Hospital at the Sun Yat-sen University, Guangzhou 510630, China.
Julie WangDivision of Rheumatology and Immunology, Department of Immunology, the School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Qiannan FangDepartment of Clinical Immunology, the Third Affiliated Hospital at the Sun Yat-sen University, Guangzhou 510630, China.
Xiaoli FanDivision of Rheumatology and Immunology, Department of Immunology, the School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Nancy OlsenDepartment of Medicine, Penn State College of Medicine, Hershey, PA 17033, USA.
Li ZhouDepartment of Oncology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Bin LiDepartment of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Song Guo ZhengDivision of Rheumatology and Immunology, Department of Immunology, the School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by abundant autoantibodies. B cells play a critical role in initiation and progress of SLE, showing immunotolerance loss, hyperactivity, and abnormal activation or maturation. Interferon regulatory factor 4 (IRF4) controls B cell differentiation; therefore, targeting IRF4 is a possible therapeutic. Here, we developed a mouse strain containing a single mutation in 123

Indexed as

Immune systemImmunology

Identifiers

PMID41280680
PMCPMC12639560

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.