Evidence map›Paper›PMID 41280697›Full record

ArticleiScience2025

Differential increase in endocannabinoid levels at the plasma and intracellular membranes.

Simar Singh, Anthony English, Jackson Yu, Dennis Sarroza, Larry Zweifel, Michael R Bruchas, Benjamin B Land, Oscar Vivas, Nephi Stella

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simar SinghDepartments of Pharmacology, University of Washington, Seattle, WA, USA.
Anthony EnglishDepartments of Pharmacology, University of Washington, Seattle, WA, USA.
Jackson YuDepartments of Pharmacology, University of Washington, Seattle, WA, USA.
Dennis SarrozaDepartments of Pharmacology, University of Washington, Seattle, WA, USA.
Larry ZweifelDepartments of Pharmacology, University of Washington, Seattle, WA, USA.
Michael R BruchasDepartments of Pharmacology, University of Washington, Seattle, WA, USA.
Benjamin B LandDepartments of Pharmacology, University of Washington, Seattle, WA, USA.
Oscar VivasDepartments of Pharmacology, University of Washington, Seattle, WA, USA.
Nephi StellaDepartments of Pharmacology, University of Washington, Seattle, WA, USA.

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · 2024 to 2025
$4.8M
Mechanisms behind the clustering of BK and calcium channelsR35GM142690 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$389k
NIDA NIH HHS P30 DA048736NIGMS NIH HHS R35 GM142690
6 · The paper itself

Abstract

Endocannabinoids (eCBs) modulate the activity of proteins expressed at the plasma and intracellular membranes. Nothing is known about the dynamic changes in eCB levels in these subcellular compartments. We leveraged the eCB sensor, GRAB

Indexed as

BiochemistryBiochemistry applicationsBiological sciencesNatural sciences

Identifiers

PMID41280697
PMCPMC12639868

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.