ArticleFood science & nutrition2025
Effects of Silver Nanoparticle-Loaded 18β-Glycyrrhetinic Acid on P2X7 Receptor and Endoplasmic Reticulum Stress-Mediated NLRP3 Inflammasome Activation in Testicular Tissue in an Animal Diabetes Model.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- 18ï ¢-Glycyrrhetinic acid suppresses glioblastoma by regulating p38 signaling pathway: an integrative approach combining network analysis, transcriptomics, and experimental assessment.Frontiers in pharmacology · 2026Article
- Effects of Silver Nanoparticle-Loaded 18β-Glycyrrhetinic Acid on P2X7 Receptor and Endoplasmic Reticulum Stress-Mediated NLRP3 Inflammasome Activation in Testicular Tissue in an Animal Diabetes Model.Food science & nutrition · 2025Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Diabetes, a metabolic disease characterized by high blood sugar, causes damage to many organs in the body. Accordingly, the present study investigates the effects of silver nanoparticle-loaded 18β-glycyrrhetinic acid (AgNP+18β-GA) on P2X7 receptor and ER stress-mediated NLRP3 inflammasome activation in testicular tissue. 42 Wistar-Albino rats aged 6 months were used. The rats were divided into the following seven groups: Control, AgNP+18β-GA100, DM, DM-18β-GA100, DM-AgNP+18β-GA50, DM-AgNP+18β-GA100, and DM-AgNP. After the experiment, sperm samples obtained from the rats were evaluated. Oxidative stress markers, serum IL-1β, and TNF-α levels were determined in the testicular tissue samples taken separately. In addition, Caspase-1, NLRP3, P2X7, Caspase-3, NF-κB, IRE1, ATF6, and CHOP protein expression levels were evaluated using Western blot analysis of histopathological examinations. Specifically, the most significant decrease was observed in NLRP3, Caspase-1, P2X7, and NF-κB levels in the DM-AgNP+18β-GA100 group (
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