Evidence map›Paper›PMID 41280902›Full record

ArticleFrontiers in immunology2025

Cannabis use is associated with alterations in NLRP3 inflammasome related gene expression in monocyte-derived macrophages from people living with HIV.

Kyle C Walter, Bryant Avalos, Mary K Ford, Anna E Laird, Ali Boustani, Matthew Spencer, Leeann Shu, Antoine Chaillon, Melanie Crescini, Debralee Cookson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kyle C Walter *Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Bryant Avalos *Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Mary K FordDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Anna E LairdDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Ali BoustaniDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Matthew SpencerDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Leeann ShuDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Antoine ChaillonDepartment of Medicine, University of California San Diego, La Jolla, CA, United States.
Melanie CresciniDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Debralee CooksonDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Ronald J EllisDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Scott L LetendreDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Jennifer IudicelloDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Jerel Adam FieldsDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.

Funding

Cannabis and Pathogenic Mechanisms influencing Blood Brain Barrier Function in HIVR01DA058405 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$1.2M
Disentangling the HIV/opioid intertwined mechanisms on mitochondrial mediated inflammasome activation, neurotoxicity and targeting strategies: In vivo and in vitro analyses of fresh human brainR01DA062278 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$794k
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$438k
NIDA NIH HHS R01 DA053052NIDA NIH HHS R01 DA058405NIDA NIH HHS R01 DA062278NIDA NIH HHS T32 DA031098
6 · The paper itself

Abstract

Introduction: Human immunodeficiency virus (HIV) infection is often associated with chronic inflammation and cognitive dysfunction in people living with HIV (PWH). The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome plays a crucial role in the secretion of pro-inflammatory cytokines, specifically interleukin (IL)-18 and IL-1β. Cannabis use and certain phytocannabinoids, such as cannabidiol (CBD), may provide therapeutic benefits in conditions associated with chronic inflammation. Methods: In this cross-sectional study, we investigated the relationship between cannabis use and Results: MDMs without treatment from PWH exhibited 83% higher Discussion: Overall, these findings suggest that CBD, as consumed through cannabis use, may mitigate NLRP3 activation in PWH, potentially offering therapeutic benefits for chronic inflammation. However, the unexpected effects on downstream cytokine mRNA expression, combined with product heterogeneity, underscore the need for future mechanistic studies to fully delineate cannabinoid-inflammasome interactions in the context of HIV.

Indexed as

HIV InfectionsInflammasomesMacrophagesMarijuana UseNLR Family, Pyrin Domain-Containing 3 ProteinAdultCannabidiolCross-Sectional StudiesFemaleGene Expression RegulationHumansInterleukin-1betaMaleMiddle AgedCannabidiolInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humancannabisCBDHIV-associated neuroinflammationmonocyte-derived macrophagesNLRP3 inflammasome

Identifiers

PMID41280902
PMCPMC12634353

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.