Evidence map›Paper›PMID 41281364›Full record

ArticlemicroPublication biology2025

Gene Expression Profile of Gm20594 and Hapln1 in Mouse Cardiac Muscle Exposed to Microgravity and Space-like Chronic Low-Dose Radiation.

Emma Mackey, Carly Orr, Azemat Jamshidi-Parsian, Stephanie Byrum, Robert Griffin, Rupak Pathak, Nathan S Reyna

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emma Mackey *Biology, Ouachita Baptist University, Arkadelphia, Arkansas, United States.
Carly Orr *Biology, Ouachita Baptist University, Arkadelphia, Arkansas, United States.
Azemat Jamshidi-Parsian *University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.
Stephanie Byrum *Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States.
Robert Griffin *University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.
Rupak Pathak *Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.
Nathan S Reyna *Biology, Ouachita Baptist University, Arkadelphia, Arkansas, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to cosmic radiation and microgravity has led to adverse health effects, including cardiac dysfunction, in astronauts after spaceflight. To better understand the underlying mechanisms, we concurrently exposed C57BL/6J mice to chronic irradiation and simulated microgravity for 30 days and collected cardiac tissue for gene expression profiling. Gm20594 and Hapln1 were found to be significantly differentiated in mouse cardiac muscle exposed to simulated microgravity and chronic irradiation. Existing literature detailing the typical function of these genes indicates that their differential expression can lead to heightened cardiovascular risk due to heart inflammation, reduced contractility, and increased apoptosis.

Identifiers

PMID41281364
PMCPMC12631252

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.