ReviewExposome2025
Oculomics meets exposomics: a roadmap for applying multi-modal ocular biomarkers in precision environmental health research.
Review in Exposome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Blood metabolomic signatures linking air pollution to lung cancer in the Cancer Prevention Studies.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Precision environmental health (PEH) is an emerging field that seeks to understand how diverse environmental exposures interact with individual biological and genetic factors to influence health outcomes. While recent advances in exposomics have enabled systematic characterization of the exposome, the integrated compilation of all physical, chemical, biological, and psychosocial influences that affect biology and health, identifying and developing sensitive biomarkers remains a critical challenge. The human eye offers unique potential for non-invasive biomarker discovery. Ocular biomarkers can be utilized not only for diagnostics and therapeutic responses of ocular diseases, but also for monitoring environmental exposures and predicting systemic health outcomes. Retinal imaging modalities such as color fundus photography, optical coherence tomography, and optical coherence tomography angiography capture biomarkers linked to environmental exposures and systemic conditions like cardiovascular and neurodegenerative diseases, a field known as oculomics. Similarly, ocular fluids, such as tears, aqueous humor and vitreous humor, may also reflect pollution-induced oxidative stress and inflammation and systemic health conditions. This paper summarizes current evidence on how ocular biomarkers can bridge environmental exposures and systemic health outcomes, and proposes future research directions using state of the art methodologies such as exposome-wide association studies, high dimensional mediation analysis, and multi-modal foundation models. Despite encouraging progress, significant challenges remain, including the need for large and standardized datasets, rigorous validation, and ethical safeguards to ensure equitable application. Advances in artificial intelligence, including federated learning, alongside global consortium efforts, will be essential to overcome these barriers. Addressing these gaps will unlock the full potential of oculomics and exposomics, advancing the goals of precision environmental health.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.