Evidence map›Paper›PMID 41282062›Full record

ArticleResearch square2025

The SMARCA5-DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline Development.

Yuka Kitamura, Yasuhisa Munakata, Hironori Abe, Mengwen Hu, Satoyo Oya, Shanmathi Murugesan, Mahnoor Rizwan, Shawna Katz, David Picketts, Richard Schultz and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuka KitamuraUniversity of California, Davis.ORCID 0009-0001-7403-0902
Yasuhisa MunakataUniversity of California, Davis.
Hironori AbeUniversity of California Davis.
Mengwen HuUniversity of California, Davis.ORCID 0000-0002-7480-6432
Satoyo OyaUniversity of California Davis.
Shanmathi MurugesanUniversity of California Davis.
Mahnoor RizwanUniversity of California Davis.
Shawna KatzUniversity of California Davis.
David PickettsOttawa Hospital Research Institute.ORCID 0000-0002-9227-2016
Richard SchultzUniversity of Pennsylvania.ORCID 0000-0001-5923-6825
Satoshi NamekawaUniversity of California Davis.ORCID 0000-0002-1052-943X

Funding

Epigenetic gene regulations in the germlineR35GM141085 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Satoshi Namekawa · 2021 to 2026
$4.4M
NICHD NIH HHS L30 HD116268NIGMS NIH HHS R35 GM141085
6 · The paper itself

Abstract

The establishment of cell type-specific chromatin landscapes is essential for cellular identity, but how these landscapes are generated remains poorly understood. Here, we demonstrate that the chromatin remodeler SMARCA5 establishes epigenetic priming that is required for retinoic acid (RA)-induced differentiation in the male germline. Germ cell-specific deletion of

Identifiers

PMID41282062
PMCPMC12632728

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.