Evidence map›Paper›PMID 41282088›Full record

ArticleResearch square2025

The Somatic Aneuploidy Landscape of Adult Glia Reveals 16p as a Hotspot and Differentiates Mosaicism in Normal Glia from Chromosomal Instability in Glioblastoma.

Cristina Montagna, Olivia Albert, Shixiang Sun, Jhih-Rong Lin, Moonsook Lee, Chang Chan, Alexander Maslov, Lisa Ellerby, Anita Huttner, Zhengdong Zhang and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in oncology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cristina MontagnaRutgers Cancer Institute.ORCID 0000-0003-2343-5851
Olivia AlbertAlbert Einstein College of Medicine.
Shixiang SunAlbert Einstein College of Medicine.ORCID 0000-0001-5499-2963
Jhih-Rong LinAlbert Einstein College of Medicine.
Moonsook LeeAlbert Einstein College of Medicine.
Chang ChanRutgers Institute of New Jersey.ORCID 0000-0001-9897-4759
Alexander MaslovAlbert Einstein College of Medicine.ORCID 0000-0001-5402-8891
Lisa EllerbyBuck Institute for Research on Aging.ORCID 0000-0002-9050-7977
Anita HuttnerYale University.
Zhengdong ZhangAlbert Einstein College of Medicine.
Jan VijgAlbert Einstein College of Medicine.ORCID 0000-0002-8457-9595

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8M
Single cell analysis coreP01AG066591 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI MELOV, SIMON · 2021 to 2025
$15.5M
Genomic Instability-Induced Senescence in Brain Aging and Alzheimer's DiseaseRF1AG068908 · NIA · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI CAMPISI, JUDITH, MONTAGNA, CRISTINA · 2020 to 2020
$1.8M
Genomic Instability-Induced Senescence in Brain Aging and Alzheimer's DiseaseR01AG068908 · NIA · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI ELLERBY, LISA M, MONTAGNA, CRISTINA · 2025 to 2025
$432k
Age associated genomic instability and brain tumor riskU01CA238726 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MONTAGNA, CRISTINA · 2019 to 2020
$251k
NCI NIH HHS P30 CA072720NCI NIH HHS U01 CA238726NIA NIH HHS P01 AG066591NIA NIH HHS R01 AG068908NIA NIH HHS RF1 AG068908NIDDK NIH HHS P60 DK020541
6 · The paper itself

Abstract

Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer and has been proposed as an initiating event in tumorigenesis. In glioblastoma (GBM), a highly aggressive brain tumor, cells almost universally display gain of chromosome 7 and loss of chromosome 10. However, it remains unclear whether these alterations arise

Indexed as

AneuploidyChromosome 16p11.2 CNVGlioblastoma (GBM)High-grade gliomaLoss of chromosome X (LoX)Non-neuronal glial cellsSingle-nucleus whole-genome sequencing (snWGS)Tumor heterogeneity

Identifiers

PMID41282088
PMCPMC12637803

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.