ArticleResearch square2025
Increasing resilience to stress by home-based transcranial stimulation.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
10 authors.
Funding
Abstract
Mental health disorders, especially anxiety and depression, affect nearly one billion people worldwide, with chronic stress playing a major role in their onset and severity. Despite growing demand, access to care remains limited, underscoring the need for scalable, preventive interventions. This study investigates the feasibility, safety, and preliminary effects of a Home-Based transcranial Direct Current Stimulation (HB-tDCS) protocol targeting the left dorsolateral prefrontal cortex (L-DLPFC) to enhance stress resilience in healthy middle-aged adults. Thirty-one participants completed ten sessions of self-administered tDCS over two weeks, monitored remotely. Adherence was high (98%), with minimal technical issues and no serious adverse events reported. Mild, transient side effects occurred in only four participants. A stress induction paradigm involving pupillometry, electrodermal activity (EDA), and subjective stress and anxiety ratings was administered pre- and post-intervention. Results indicated a significant reduction in acute stress appraisal, but no significant changes in anxiety scores or physiological markers. These findings support the feasibility and safety of HB-tDCS and suggest potential stress-reducing effects, though the absence of a control group and limited psychophysiological impact warrant cautious interpretation. Future research should explore longer stimulation protocols, controlled trials, and clinical applications in populations with heightened stress vulnerability.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.