Evidence map›Paper›PMID 41282121›Full record

ArticleResearch square2025

Cytosolic mtDNA and associated EYA-mediated pro-inflammatory signaling modulate healthspan in Drosophila.

David Walker, Ricardo Aparicio, Roberta Alessi, Agathe Solans, Matin Mojdeh, Vartika Sharma, Paul Oh, Matea Zelich, Toby Frank, Jae Hur

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David WalkerUniversity of California, Los Angeles.ORCID 0000-0002-9422-2178
Ricardo AparicioUniversity of California, Los Angeles.ORCID 0000-0003-3670-0466
Roberta AlessiUniversity of California, Los Anlgeles.
Agathe SolansUniversity of California, Los Anlgeles.
Matin MojdehUniversity of California, Los Anlgeles.
Vartika SharmaUniversity of California, Los Anlgeles.
Paul OhHarvey Mudd College.ORCID 0009-0005-2263-8157
Matea ZelichHarvey Mudd College.ORCID 0009-0008-5928-5318
Toby FrankHarvey Mudd College.
Jae HurHarvey Mudd College.

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Role of Mitochondrial Homeostasis in Animal AgingR01AG037514 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David W Walker · 2010 to 2026
$5.3M
Role of Intestinal Homeostasis in Organismal Aging.R01AG049157 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WALKER, DAVID W · 2015 to 2025
$2.4M
NIA NIH HHS R01 AG037514NIA NIH HHS R01 AG049157NIH HHS P40 OD018537
6 · The paper itself

Abstract

Mitochondrial dysfunction and pro-inflammatory signaling are each key drivers of aging. However, a clear understanding of the connections between mitochondrial homeostasis, inflammation and lifespan determination remains elusive. Upon mitochondrial stress or damage, mtDNA can be released into the cytosol thus encountering cytosolic DNA sensors and activating pro-inflammatory responses. Here, we report a striking age-related increase in cytosolic mtDNA, which can be counteracted by mitophagy, in

Indexed as

cognitive functionDNautophagyNuclease activity

Identifiers

PMID41282121
PMCPMC12633184

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.