Evidence map›Paper›PMID 41282131›Full record

ArticleResearch square2025

The human vagal complex: from gross anatomy to single neurons, from brainstem to abdomen.

Nicole A Pelot, Ian Baumgart, Ari Blitz, Brandon A S Brunsman, Eleana Cintron, Jennifer J Coleman, Andrew R Crofton, Jennifer D'Silva, Chris Flask, Aniya Hartzler and 25 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Nicole A PelotDepartment of Biomedical Engineering, Duke University, Durham, NC, USA, 27708.ORCID 0000-0003-2844-0190
Ian BaumgartDepartment of Biomedical Engineering, Duke University, Durham, NC, USA, 27708.
Ari BlitzDepartment of Radiology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA, 44106.
Brandon A S BrunsmanDepartment of Anatomy, Case Western Reserve University, Cleveland, OH, USA, 44106.
Eleana CintronDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Jennifer J ColemanDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Andrew R CroftonDepartment of Anatomy, Case Western Reserve University, Cleveland, OH, USA, 44106.
Jennifer D'SilvaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Chris FlaskDepartment of Radiology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA, 44106.
Aniya HartzlerDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Daniel A HerzkaDepartment of Radiology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA, 44106.
Proapa IslamDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Michael W JenkinsDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Talya A JeterDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Naomi JosephDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Beverly KoepfCleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA, 44106.
Chaitanya KolluruDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Shruti KumariDepartment of Radiology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA, 44106.
Valerie H LamDepartment of Anatomy, Case Western Reserve University, Cleveland, OH, USA, 44106.
Leina LunascoDepartment of Anatomy, Case Western Reserve University, Cleveland, OH, USA, 44106.ORCID 0000-0003-3403-7429
Michael MarkleyDepartment of Radiology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA, 44106.
Noa B NuzovDepartment of Anatomy, Case Western Reserve University, Cleveland, OH, USA, 44106.
Ashley OnabiyiDepartment of Anatomy, Case Western Reserve University, Cleveland, OH, USA, 44106.
Tatiana PascolDepartment of Anatomy, Case Western Reserve University, Cleveland, OH, USA, 44106.
Rebecca PrinceDepartment of Anatomy, Case Western Reserve University, Cleveland, OH, USA, 44106.
Zeyna SambaDepartment of Anatomy, Case Western Reserve University, Cleveland, OH, USA, 44106.
James SecklerDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Anandakumar ShunmugavelDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Mallika SinghDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Sunah SongCleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA, 44106.ORCID 0000-0002-3139-0035
Aniruddha UpadhyeDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
David L WilsonDepartment of Radiology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA, 44106.
Katharine WorkmanDepartment of Anatomy, Case Western Reserve University, Cleveland, OH, USA, 44106.
Jichu ZhangDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.
Andrew J ShoffstallDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA, 44106.

Funding

RECONSTRUCTING VAGAL ANATOMY75N98022C00018 · OD · CASE WESTERN RESERVE UNIVERSITY · PI SHOFFSTALL, ANDREW · 2022 to 2024
$15.8M
3D Microscopy with Ultraviolet Surface Excitation (3D-MUSE)R01EB028635 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI LEVENSON, RICHARD M., WILSON, DAVID LYNN · 2019 to 2023
$2.7M
BLRD VA IS1 BX004384NIBIB NIH HHS R01 EB028635NIH HHS 75N98022C00018
6 · The paper itself

Abstract

The vagus nerve (VN) connects the brainstem to the viscera to regulate many physiological functions. Mapping the VN with state-of-the-art high-resolution imaging modalities has tremendous potential to improve the safety and efficacy of existing autonomic neuromodulation therapies and to inform design of new therapies. We developed the most comprehensive mapping pipeline of the VN to date, from the perspectives of sample size, lengths of nerve, and range of imaging modalities. Our pipeline maps cadaveric human vagal anatomy with complementary imaging modalities applied serially to the same tissue: pre-dissection MRI, pre-dissection CT, 3D tracing of the dissected nerve

Identifiers

PMID41282131
PMCPMC12633527

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.