Evidence map›Paper›PMID 41282135›Full record

ArticleResearch square2025

Insights into rhodopsin molecular evolution from mice with "humanized" Phe-88 to Leu substitution.

Feifei Wang, Alexander V Kolesnikov, Shinya Sato, Aneal Singh, Clint L Makino, Pere Garriga, Vladimir J Kefalov

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Feifei WangGrup de Biotecnologia Molecular i Industrial, Centre de Biotecnologia Molecular, Departament d'Enginyeria Quimica, Universitat Politècnica de Catalunya-Barcelona Tech, Edifici Gaia, Rambla de Sant Nebridi 22, 08222 Terrassa, Catalonia, Spain.
Alexander V KolesnikovGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, California, 92697, USA.
Shinya SatoGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, California, 92697, USA.
Aneal SinghGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, California, 92697, USA.
Clint L MakinoDepartment of Physiology and Biophysics, University of California Irvine, Irvine, California, 92697, USA; Department of Pharmacology, Physiology and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, 02118, USA.
Pere GarrigaGrup de Biotecnologia Molecular i Industrial, Centre de Biotecnologia Molecular, Departament d'Enginyeria Quimica, Universitat Politècnica de Catalunya-Barcelona Tech, Edifici Gaia, Rambla de Sant Nebridi 22, 08222 Terrassa, Catalonia, Spain.
Vladimir J KefalovGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, California, 92697, USA.

Funding

NEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vladimir Jivkov Kefalov · 2022 to 2026
$3.7M
Molecular mechanism of the visual disorders caused by G90D and G90V rhodopsin mutationsR01EY035884 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vladimir Jivkov Kefalov · 2024 to 2026
$1.7M
Modulation of cone photoreceptor function by autophagyR01EY035137 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Thomas Almon Ferguson, Vladimir Jivkov Kefalov · 2023 to 2026
$1.5M
NEI NIH HHS P30 EY034070NEI NIH HHS R01 EY035137NEI NIH HHS R01 EY035884
6 · The paper itself

Abstract

The function of rod photoreceptors as dim light photon detectors depends critically on the molecular properties of their visual pigment, rhodopsin. The structure of rhodopsin has evolved under selective pressure to light conditions of different spectral composition and overall intensity. One notable example is the switch of mammalian species from nocturnal to diurnal environments. Comparison of the rhodopsins of the nocturnal mouse and the diurnal human reveals high sequence similarity, with only 18 distinct amino acids. Here, we examined the role of one of these, mouse phenylalanine (F) vs. human leucine (L) at position 88, in modulating the molecular properties of rhodopsin and the function of rods by generating F88L rhodopsin knock-in mouse. Our detailed

Indexed as

Diurnal visionMolecular evolutionNocturnal visionPhototransductionRhodopsin

Identifiers

PMID41282135
PMCPMC12633206

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.