Evidence map›Paper›PMID 41282203›Full record

ArticleResearch square2025

Rapid Functional Drug Screening of Passage-Zero Patient Brain Tumor Tissues Ex Vivo: Results from a Clinical Feasibility Study.

Andrew Satterlee, Breanna Mann, Nichole Artz, Adebimpe Adefolaju, Alain Valdivia, Xiaopei Zhang, Rajaneekar Dasari, Caroline Stockwell, Morrent Thang, Allison Murray and 24 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Andrew SatterleeUniversity of North Carolina at Chapel Hill.ORCID 0000-0001-6952-5823
Breanna MannUniversity of North Carolina at Chapel Hill.
Nichole ArtzUniversity of North Carolina at Chapel Hill.
Adebimpe AdefolajuUniversity of North Carolina at Chapel Hill.
Alain ValdiviaUniversity of North Carolina at Chapel Hill.
Xiaopei ZhangUniversity of North Carolina at Chapel Hill.
Rajaneekar DasariUniversity of North Carolina at Chapel Hill.
Caroline StockwellUniversity of North Carolina at Chapel Hill.
Morrent ThangUniversity of North Carolina at Chapel Hill.
Allison MurrayUniversity of North Carolina at Chapel Hill.
Noah BellUniversity of North Carolina at Chapel Hill.
Andrew BuckleyUniversity of North Carolina at Chapel Hill.
Rami DarawshehUniversity of North Carolina at Chapel Hill.
Kerry FitzgeraldLabcorp.
Jonathan WilliamsLabcorp.
Hardik ParikhLabcorp.
Shuang GaoLabcorp.
Jie AnLabcorp.
Yvette RodriguezLabcorp.
Daniel MetzgerLabcorp.
Collin ParrowLabcorp.
Dylan RileyLabcorp.
Robert SeagerLabcorp.
Stephanie HastingsLabcorp.
Taylor JensenLabcorp.
Shakti RamkissoonLabcorp Oncology.
Dominique HigginsUniversity of North Carolina at Chapel Hill.
Yasmeen RaufUniversity of North Carolina at Chapel Hill.
Scott EltonUniversity of North Carolina at Chapel Hill.
Kimberly HamiltonUniversity of North Carolina at Chapel Hill.
Jeremy WangUniversity of North Carolina at Chapel Hill.ORCID 0000-0002-0673-9418
Albert BaldwinUniversity of North Carolina at Chapel Hill.
Shawn HingtgenUniversity of North Carolina at Chapel Hill.
David KramUniversity of North Carolina at Chapel Hill.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HONG JIN KIM · 1985 to 2026
$201.5M
CTSA K12 Program at UNCK12TR004416 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michelle Hernandez, Jonathan J Juliano · 2023 to 2026
$6.5M
A consortium effort to translate therapies for neurological diseases via an ex vivo organotypic platformU01TR003715 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BALDWIN, ALBERT SIDNEY, FLORES, CATHERINE T · 2021 to 2024
$4.6M
Enhancement Training for the Next Generation of Translational Ph.D. ScientistsT32GM122741 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOLBERG, ALISA S., YEH, JEN JEN · 2018 to 2022
$898k
NCATS NIH HHS K12 TR004416NCATS NIH HHS U01 TR003715NCI NIH HHS P30 CA016086NIGMS NIH HHS T32 GM122741
6 · The paper itself

Abstract

Functional precision medicine (FPM) offers a promising path forward in neuro-oncology, where genomic profiling alone often fails to predict therapeutic response. To bridge this gap, we developed the Screening Live Cancer Explants (SLiCE) platform, a rapid

Identifiers

PMID41282203
PMCPMC12637813

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.