ArticleClinical kidney journal2025
Severe obesity associates with maladaptive glomerular haemodynamics clustered with insulin resistance and endothelial dysfunction.
Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dual Burden of Kidney Disease and Cognitive Impairment in the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia-Cohort.Kidney international reports · 2026Article
- A Dynamic Online Nomogram for Predicting Postoperative Acute Kidney Injury After Sleeve Gastrectomy.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Association Between Estimated Glucose Disposal Rate and Chronic Kidney Disease in Elderly Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study in Zhejiang, China.Clinical interventions in aging · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Obesity is a leading risk factor for chronic kidney disease, with glomerular hyperfiltration as one of its earliest manifestations. However, absolute glomerular filtration rate (GFR) does not distinguish well between a pressure-driven hyperfiltration and the physiological forms. Insulin resistance and endothelial dysfunction have been proposed as key correlates of maladaptive renal haemodynamics, but their interplay remains unclear. Methods: Cross-sectional pilot study involving 27 adults with severe obesity (mean body mass index of 43.9 kg/m²). Measured GFR (mGFR) was assessed by iohexol plasma clearance and effective renal plasma flow (ERPF) by Results: Participants were stratified into tertiles of P-score. Across tertiles, mGFR did not differ, but ERPF declined (756 ± 113 vs 505 ± 130 mL/min, Conclusion: A maladaptive phenotype characterized by elevated filtration fraction relative to renal plasma flow clustered with insulin resistance and endothelial dysfunction, whereas mGFR alone failed to capture these relationships. Comprehensive haemodynamic profiling may help to refine risk stratification in obesity.
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