Evidence map›Paper›PMID 41282506›Full record

ReviewBiomedical reports2026

Potential of organ-on-a-chip in advancing synthetic extracellular matrix technology for bone tissue engineering in dentistry (Review).

Muhammad Hidayat Syahruddin, Ika Dewi Ana, Dmitry Belyaev, Dyah Irnawati, Hevi Wihadmadyatami, Natalia Beshchasna, Rahmi Anggraeni

Abstract readReview
In one paragraph

Review in Biomedical reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Muhammad Hidayat SyahruddinDoctoral Program in Dental Sciences, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Ika Dewi AnaCenter of Excellence for Carbonate Apatite-based Extracellular Matrix and Adjuvant, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Dmitry BelyaevDepartment of Bio- and Nanotechnology, Group of Biodegradation and Nanofunctionalization, Fraunhofer Institute for Ceramic Technologies and Systems, D-01109 Dresden, Germany.
Dyah IrnawatiDepartment of Dental Biomaterials Sciences, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Hevi WihadmadyatamiResearch Collaboration Center for Biomedical Scaffolds, National Research and Innovation Agency-Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Natalia BeshchasnaDepartment of Bio- and Nanotechnology, Group of Biodegradation and Nanofunctionalization, Fraunhofer Institute for Ceramic Technologies and Systems, D-01109 Dresden, Germany.
Rahmi AnggraeniResearch Collaboration Center for Biomedical Scaffolds, National Research and Innovation Agency-Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone tissue engineering (BTE) is a cutting-edge approach within biomedical sciences, especially in regenerative medicine, addressing key challenges such as organ transplantation and complex tissue repair. At the core of BTE is the development of biomimetic scaffolds to replicate native tissue environments. However, conventional models often fall short in accurately mimicking the complexity of human tissue microenvironments. Organ-on-a-chip (OOAC) technology offers a transformative alternative. These microscale systems combine microfluidics, biomaterials and cell cultures to emulate the structural and functional characteristics of human tissue. OOAC platforms facilitate dynamic, real-time evaluation of scaffold biocompatibility, cellular interactions and mechanical properties under physiological conditions. By overcoming the limitations of traditional preclinical models, OOAC systems minimize the need for animal testing, improve predictive accuracy for

Indexed as

bioengineeringbiomedicinedentistrymicrofluidicsorgan-on-a-chipscaffoldsustainable development goal

Identifiers

PMID41282506
PMCPMC12635794

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.