Evidence map›Paper›PMID 41282516›Full record

ArticleJAR life2025

The association between medication use and lifestyle factors in independently living older people: impact of Mediterranean diet and physical activity.

Lieke Roeke, Greg Kennedy, Denny Meyer, Michael Kingsley, Catherine Itsiopoulos, Leonie Segal, Anne-Marie Minihane, Karen J Murphy, Tuan Anh Nguyen, Jeffery M Reddan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAR life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lieke RoekeCentre for Mental Health and Brain Sciences, Swinburne University, Melbourne, VIC 3122, Australia.
Greg KennedyCentre for Mental Health and Brain Sciences, Swinburne University, Melbourne, VIC 3122, Australia.
Denny MeyerCentre for Mental Health and Brain Sciences, Swinburne University, Melbourne, VIC 3122, Australia.
Michael KingsleyDepartment of Exercise Sciences, University of Auckland, New Zealand.
Catherine ItsiopoulosSchool of Health and Biomedicine STEM College, RMIT University, Australia.
Leonie SegalHealth Economics and Social Policy, Allied Health and Human Movement, University of South Australia, Australia.
Anne-Marie MinihaneNutrition and Preventive Medicine, Norwich Medical School University of East Anglia, Norwich, UK.
Karen J MurphyAlliance for Research in Exercise, Nutrition and Activity (ARENA), Clinical Health Sciences, University of South Australia, Australia.
Tuan Anh NguyenSocial Gerontology Division, National Ageing Research Institute, Australia.
Jeffery M ReddanCentre for Mental Health and Brain Sciences, Swinburne University, Melbourne, VIC 3122, Australia.
Joris C VersterCentre for Mental Health and Brain Sciences, Swinburne University, Melbourne, VIC 3122, Australia.
Andrew PipingasCentre for Mental Health and Brain Sciences, Swinburne University, Melbourne, VIC 3122, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Adherence to the Mediterranean diet (MedDiet) and engagement in physical activity (PA) are associated with a lower risk of chronic disease, yet their relationship with medication use in older adults is less clear. This study examined cross-sectional associations between MedDiet adherence, PA levels, and medication use, including polypharmacy, in independently living older Australians. Design: A cross-sectional observational study. Setting and participants: Baseline data were drawn from the MedWalk trial, including 161 participants (119 females, 42 males; aged 60-90 years) residing in independent living facilities in Adelaide and Melbourne, and the wider Melbourne community. Measurements: Adherence to the MedDiet was assessed using the 14-item Mediterranean Diet Adherence Screener (MEDAS). PA was objectively measured via accelerometry and categorized as low (<150 min/week), moderate (150-<300 min/week), or high (≥300 min/week) of moderate-to-vigorous PA. Medication use was self-reported and coded using Anatomical Therapeutic Chemical (ATC) classifications. Polypharmacy was defined as use of ≥5 medications. Logistic and negative binomial regression analyses were adjusted for age, sex, education, and BMI. Results: Moderate and high PA were associated with significantly lower odds of polypharmacy compared with low PA (AOR=0.37, Conclusion: In this cross-sectional study, higher PA was consistently associated with reduced polypharmacy and fewer medications, while greater MedDiet adherence was linked to reduced use of metabolic medications. Lifestyle practices may influence medication use patterns in later life. Larger longitudinal studies are needed to clarify causality and inform strategies to reduce polypharmacy through promotion of healthy lifestyle behaviors.

Indexed as

Lifestyle factorsMedication useMediterranean dietOlder adultsPhysical activity

Identifiers

PMID41282516
PMCPMC12639465

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.