Evidence map›Paper›PMID 41282533›Full record

ArticleRegenerative biomaterials2025

ROS-triggered hydrophilicity switching synergizes with pH-responsive nanocarriers for therapy of diabetic wound.

Bin Yin, Yueying Fan, Jinfu Li, Cheng Li, Shiqiang Jiang, Xiangyang Li, Chao Yan, Jiaxin Jiang, Peng Wang, Chiyu Jia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bin YinCenter of Burn & Plastic and Wound Healing Surgery, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Yueying FanCenter of Burn & Plastic and Wound Healing Surgery, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Jinfu LiCenter of Burn & Plastic and Wound Healing Surgery, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Cheng LiCenter of Burn & Plastic and Wound Healing Surgery, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.ORCID https://orcid.org/0009-0000-3615-9310
Shiqiang JiangCenter of Burn & Plastic and Wound Healing Surgery, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Xiangyang LiCenter of Burn & Plastic and Wound Healing Surgery, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Chao YanCenter of Burn & Plastic and Wound Healing Surgery, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Jiaxin JiangGuangdong Huayi Biomedical Science and Technology Center, Guangzhou, Guangdong 511450, China.
Peng WangCenter of Burn & Plastic and Wound Healing Surgery, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Chiyu JiaCenter of Burn & Plastic and Wound Healing Surgery, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic diabetic wounds are notoriously difficult to heal due to the self-perpetuating cycle of persistent inflammation and oxidative stress, while current therapies are limited by single-action mechanisms and inefficient drug delivery. This study developed a reactive oxygen species (ROS)/pH dual-responsive hydrophilicity switching intelligent hydrogel (GC-HA@ZIF-8@Cur) by integrating a zeolitic imidazolate framework-8 (ZIF-8) with a dynamically crosslinked hydrogel for synergistic therapy. The system employs inflammation-targeting hyaluronic acid (HA)-modified ZIF-8 nanoparticles (HA@ZIF-8@Cur) to encapsulate curcumin (Cur), which are embedded into a ROS-responsive hydrogel matrix formed by ultraviolet-initiated polymerization of methacrylated gelatin and lipoic acid-grafted chitosan. In the ROS microenvironment of diabetic wounds, oxidation of thioether bonds in the hydrogel to sulfoxide bonds enhanced the hydrophilicity, while acidic conditions induced pH-responsive dissociation of ZIF-8 to cascade-release Cur and Zn

Indexed as

anti-inflammatorycurcumindiabetic chronic woundshydrophilicity switchingROS/pH dual-responsive

Identifiers

PMID41282533
PMCPMC12639545

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.