Evidence map›Paper›PMID 41282739›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Human genetic variation associates with infection by derived Ugandan M. tuberculosis lineage.

Catherine M Stein, Penelope Benchek, Lentlamatse Mantshoyane, Timothy Ciesielski, Michael L McHenry, Himiede Wilson-Sesay, Moses Joloba, Eddie Wampande, Kimberly A Dill Mc-Farland, Allison W Roberts and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Catherine M Stein
Penelope Benchek
Lentlamatse Mantshoyane
Timothy Ciesielski
Michael L McHenry
Himiede Wilson-Sesay
Moses Joloba
Eddie Wampande
Kimberly A Dill Mc-Farland
Allison W Roberts
Ben Polacco
Max Bennett
Nevan KroganORCID 0000-0003-4902-337X
W Henry Boom
Jeffery S Cox
Harriet Mayanja-Kizza
Thomas R Hawn
Scott M Williams

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies examined host and pathogen genetic influences on tuberculosis (TB) susceptibility separately, but relatively few studied their combined effects. However, host-pathogen interactions or co-evolution may explain the inability to replicate many reported human genetic effects across global populations and provide additional insight into TB risk. In this study, we address such possible interactions by focusing on the outcome of infection with L4-Uganda

Identifiers

PMID41282739
PMCPMC12636655

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.