ArticlemedRxiv : the preprint server for health sciences2025
Common genetic variants near
Registry-linked trialAbstract readPreprint
In one paragraph
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01794143. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study
PMID 38285957PMID 37213109PMID 38194519PMID 38416773PMID 39998948PMID 38227900PMID 40388190PMID 38190625PMID 38190619PMID 38211595PMID 32139384PMID 23690531other papers from this trial
Open the trial in the graphWho cites it
0 citing papers in PubMed.
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors.
Josephine H LiCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA.ORCID 0000-0003-2314-0914
Lukasz SzczerbinskiDiabetes Unit, Massachusetts General Hospital and Department of Medicine, Mass General Brigham, Boston, MA.ORCID 0000-0002-6201-0605
Mark TripputiThe Biostatistics Center, Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Rockville, MD.ORCID 0000-0002-5510-7310
Haiyin LiuThe Biostatistics Center, Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Rockville, MD.
Stella NamCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA.ORCID 0000-0002-9049-2680
Endrina MujicaThe Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.ORCID 0000-0003-1348-8765
Anastasia EmmanouilidouThe Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.ORCID 0000-0003-1512-5634
Thinley Yidzin WangdenCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA.ORCID 0009-0002-9916-6360
Anna Citko-RojewskaClinical Research Center, Medical University of Bialystok, Bialystok, Poland.ORCID 0000-0003-3126-7093
Paulina KonopkaClinical Research Center, Medical University of Bialystok, Bialystok, Poland.ORCID 0000-0003-3568-8530
Marcin CzajkowskiCenter for Digital Medicine, Medical University of Bialystok, Bialystok, Poland.ORCID 0000-0002-3967-1819
Alicia Huerta-ChagoyaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA.ORCID 0000-0001-6218-3904
Maheak VoraCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA.ORCID 0000-0002-3248-9547
Aaron LeongDiabetes Unit, Massachusetts General Hospital and Department of Medicine, Mass General Brigham, Boston, MA.
James B MeigsPrograms in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA.ORCID 0000-0002-2439-2657
Maggie Y NgVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN.
Ruth J F LoosNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8532-5087
Marie PigeyrePopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada.ORCID 0000-0003-2984-8366
Hertzel C GersteinPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada.ORCID 0000-0001-8072-2836
Filipe A MouraSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT.ORCID 0000-0001-8017-1675
Yi-Pin LaiTIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-6550-8329
Deepak L BhattMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-1278-6245
Nicholas A MarstonTIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-6164-4617
Christian T RuffTIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Marc S SabatineTIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-0691-3359
Adam Y DawedDivision of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
Ewan R PearsonDivision of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.ORCID 0000-0001-9237-8585
Leslie S SatinDepartment of Pharmacology, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-1355-8647
Marcel den HoedDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.ORCID 0000-0001-8081-428X
Adam KretowskiClinical Research Center, Medical University of Bialystok, Bialystok, Poland.ORCID 0000-0002-4522-4978
Steven E KahnDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA.ORCID 0000-0001-7307-9002
Naji YounesThe Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.ORCID 0000-0002-8913-0340
Josep M MercaderCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA.ORCID 0000-0001-8494-3660
Jose C FlorezCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA.ORCID 0000-0002-1730-9325
Funding
Continuation of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) StudyU01DK098246 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI Heidi Krause-Steinrauf, JOHN M LACHIN · 2021 to 2022
$21.0MVector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · 1986 to 2025
$12.6MVanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR002243 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2025 to 2025
$10.7MWashington University Institute of Clinical and Translational SciencesUL1TR002345 · WASHINGTON UNIVERSITY · 2025 to 2025
$9.3MGeorgia Clinical & Translational Science Alliance (Georgia CTSA)UL1TR002378 · EMORY UNIVERSITY · 2025 to 2025
$9.3MPilot and Feasibility ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 to 2025
$4.9MLouisiana Clinical and Translational Science CenterU54GM104940 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2025 to 2025
$3.9MNYR-Diabetes Research Center (NYR-DRC)P30DK020541 · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2025 to 2025
$2.4MPilot and Feasibility ProgramP30DK072476 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2005 to 2025
$2.2MUAB Diabetes Research CenterP30DK079626 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$1.3MDevelopment of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple AncestriesU01HG011723 · BROAD INSTITUTE, INC. · 2025 to 2025
$949kGEneration and assessment of Multi-omic informed Subtypes of Type 2 Diabetes in Diverse Populations (GEMS-T2D)U01DK140757 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$784kNCATS NIH HHS UL1 TR000170NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001102NCATS NIH HHS UL1 TR001108NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001425NCATS NIH HHS UL1 TR001449NCATS NIH HHS UL1 TR002243NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1 TR002378NCATS NIH HHS UL1 TR002489NCATS NIH HHS UL1 TR002529NCATS NIH HHS UL1 TR002535NCATS NIH HHS UL1 TR002537NCATS NIH HHS UL1 TR002541NCATS NIH HHS UL1 TR002548NHGRI NIH HHS U01 HG011723NHLBI NIH HHS K08 HL153950NIDDK NIH HHS K23 DK131345NIDDK NIH HHS L30 DK106874NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK072476NIDDK NIH HHS P30 DK079626NIDDK NIH HHS P30 DK092926NIDDK NIH HHS R01 DK123019NIDDK NIH HHS R01 DK137993NIDDK NIH HHS U01 DK098246NIDDK NIH HHS U01 DK140757NIDDK NIH HHS U34 DK088043NIGMS NIH HHS U54 GM104940
Abstract
Optimizing second-line therapy for type 2 diabetes is challenging due to interindividual variability in response. We conducted a pharmacogenomic genome-wide association study (GWAS) in the Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness (GRADE) Study to identify genetic predictors of glycemic response to insulin glargine, glimepiride, liraglutide, and sitagliptin, when added to metformin in a diverse population. We identified 21 genome-wide significant loci associated with treatment response. rs1905505, a non-coding variant near Clinical Trial registration number: NCT01794143.
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT01794143ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.