ArticlemedRxiv : the preprint server for health sciences2025
Impact of mid-life cardiovascular health on cognitive change in a bi-ethnic cohort.
Janette Vazquez, Rebecca Bernal, Luis A Aguirre, Jesus D Melgarejo, Gladys Maestre, Sudha Seshadri, Helen P Hazuda, Chen-Pin Wang, Claudia L Satizabal
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Janette VazquezGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, Texas, USA.ORCID 0000-0002-2212-5045 Rebecca BernalGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, Texas, USA.
Luis A AguirreGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, Texas, USA.
Jesus D MelgarejoInstitute of Neuroscience, Neuro and Behavioral Health Integrated Unit, School of Medicine, University of Texas Rio Grande Valley, Harlingen, Texas, USA.
Gladys MaestreInstitute of Neuroscience, Neuro and Behavioral Health Integrated Unit, School of Medicine, University of Texas Rio Grande Valley, Harlingen, Texas, USA.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, Texas, USA.ORCID 0000-0001-6135-2622 Helen P HazudaGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, Texas, USA.
Chen-Pin WangGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, Texas, USA.
Claudia L SatizabalGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, Texas, USA.ORCID 0000-0002-1115-4430 Funding
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0MThe San Antonio Heart and Mind StudyR01AG082360 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SATIZABAL, CLAUDIA L · 2023 to 2025
$9.3MPATHOBIOLOGY OF OCCLUSIVE VASCULAR DISEASET32HL007446 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jean Chrisostome Bopassa · 1985 to 2026
$8.9MDISABLEMENT IN AN AGING BI-ETHNIC COHORTR01AG016518 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI HAZUDA, HELEN PAULINE · 2000 to 2004
$4.8MMultiethnic Validation of VCID Biomarkers in South TexasU01NS125513 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SATIZABAL, CLAUDIA L · 2023 to 2025
$3.3MMultiethnic Validation of VCID biomarkers in South TexasUF1NS125513 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SATIZABAL, CLAUDIA L · 2021 to 2021
$2.4MNHLBI NIH HHS T32 HL007446NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG016518NIA NIH HHS R01 AG082360NINDS NIH HHS U01 NS125513NINDS NIH HHS UF1 NS125513
6 · The paper itselfAbstract
introductionVascular risk factors contribute to cognitive decline and dementia; however, research across populations remains scarce.
methodsWe included 402 participants (mean age 57.9±3.8, 58.5% female, 52% Mexican American). Midlife cardiovascular health was assessed using the AHA Life's Simple 7 (LS7). General cognition was measured four times over a period of 9.5 years. We used generalized estimating equations to assess the association of LS7 scores and its factors with cognitive change, overall and by ethnicity.
resultsMeeting intermediate or ideal physical activity goals mitigated cognitive decline, particularly in Mexican Americans, and maintaining blood glucose below 125 mg/dL was associated with slower cognitive decline among non-Hispanic Whites. Additionally, Mexican Americans with a BMI <30 kg/m DISCUSSION: Physical activity, blood glucose, and BMI have distinct contributions to cognitive change across different ethnicities.
Indexed as
AHA Life’s Simple 7 (LS7)bi-ethnic populationsblood glucosecardiovascular risk factorscognitive declinecognitive trajectoriesgeneralized estimating equations (GEE)Mexican Americansmid-lifeMMSEmodifiable risk factorsphysical activitypreventative measures
Identifiers
PMID41282848
PMCPMC12633593
What Socratic holds
Textmetadata
LicenceCC BY
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