Evidence map›Paper›PMID 41282866›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Polygenic Determinants of Arterial Stiffness: Implications for Hypertension.

Adam D Gepner, Ryan J Pewowaruk, Claudia E Korcarz, Adriana Hung, Kent D Taylor, Y-D Ida Chen, Alexis C Wood, Jie Yao, Xiuqing Guo, Jerome I Rotter

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adam D GepnerWilliam S. Middleton Memorial Veteran's Hospital, Department of Medicine - Division of Cardiovascular Medicine, Madison, WI, USA.ORCID 0000-0002-5869-2850
Ryan J PewowarukWilliam S. Middleton Memorial Veteran's Hospital, Department of Medicine - Division of Cardiovascular Medicine, Madison, WI, USA.ORCID 0000-0003-1190-7196
Claudia E KorcarzWilliam S. Middleton Memorial Veteran's Hospital, Department of Medicine - Division of Cardiovascular Medicine, Madison, WI, USA.ORCID 0000-0001-9691-9027
Adriana HungNashville VA, Tennessee Valley Healthcare System, Nashville, TN, USA.ORCID 0000-0002-3203-1608
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.ORCID 0000-0002-2756-4370
Y-D Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.ORCID 0000-0003-1741-3517
Alexis C WoodUSDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston TX.ORCID 0000-0001-7616-2119
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.ORCID 0000-0002-8822-0651
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.ORCID 0000-0002-5264-5068
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.ORCID 0000-0001-7191-1723

Funding

UCLA Clinical and Translational Science InstituteUL1TR001881 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$9.9M
Pilot & Feasibility ProgramP30DK063491 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2003 to 2025
$5.4M
MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), COORDINATING CENTER - TASK AREA A - CORE STUDY OPERATIONS75N92020D00001 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$972k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · JOHNS HOPKINS UNIVERSITY · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · COLUMBIA UNIVERSITY HEALTH SCIENCES · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · WAKE FOREST UNIVERSITY · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · NORTHWESTERN UNIVERSITY · 1999 to 2001
$511k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · UNIVERSITY OF MINNESOTA TWIN CITIES · 1999 to 2001
$443k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095168 · JOHNS HOPKINS UNIVERSITY · 1999 to 2000
$375k
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · UNIVERSITY OF WASHINGTON · 1999 to 2005
$304k
CSRD VA I01 CX001897NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL105756NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

Background: Components of arterial stiffness (structural stiffness from aging and load-dependent stiffness from high blood pressure) are markers for cardiovascular disease risk. We evaluated relationships between polygenic risk scores (PRS) for blood pressure (BP) and arterial stiffness. Methods: Participants (n=5942) are from the Multi-Ethnic Study of Atherosclerosis with measures of carotid ultrasound and genomic DNA. Pulse wave velocity (PWV) was calculated from carotid ultrasound representing total stiffness. Structural stiffness was calculated by adjusting PWV to a 120/80 mmHg blood pressure with participant-specific models. Load-dependent stiffness was the difference of total and structural stiffness. Blood pressure PRSs were previously derived from a genome-wide association study. Associations between BP PRSs and components of carotid arterial stiffness were assessed with multivariable-adjusted regression models. Mendelian Randomization (MR) was performed with two-stage least squares to 1) confirm that BP PRSs strongly predict MAP and 2) estimate the effect of MAP on arterial stiffness. Results: Participants (n=5,942) were mean (standard deviation) age of 62.8 (10.3) years (52% female; 39% White, 25% African-American, 13% Asian, 23% Hispanic). Systolic BP (SBP) was 133.5 (20.5) mmHg, diastolic BP (DBP) was 74.27 (10.28) mmHg and pulse pressure (PP) was 59.22 (16.17) mmHg. Total carotid stiffness was associated with the SBP PRS (β=0.10 +/- 0.02, p=5.25E-08) and the DBP PRS (β: 0.08 +/- 0.02, p=7.26E-07) but not PP PRS (β=0.04 +/- 0.02, P=0.05). Load dependent carotid stiffness was associated with the SBP PRS β=0.09 +/- 0.01, p=7.93*10 Conclusion: There are key differences in the genetic underpinnings of the mechanistic components of arterial stiffness.

Identifiers

PMID41282866
PMCPMC12633586

What Socratic holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.