Evidence map›Paper›PMID 41282909›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Sotatercept Improves Small Airway Disease and Hyperinflation in Patients with Pulmonary Hypertension.

Hooman D Poor, Jimmy Zhang, Simone Hannah-Clark, Shyla Saini, Elliot Eisenberg, Jing Wang, Alison G Lee, Gregory Serrao, Helena Schotland, Linda Rogers and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Hooman D PoorDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Jimmy ZhangDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Simone Hannah-ClarkDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Shyla SainiDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Elliot EisenbergDivision of Pulmonary, White Plains Hospital, White Plains, NY.
Jing WangDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Alison G LeeDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Gregory SerraoDivision of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY.
Helena SchotlandDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Linda RogersDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Benjamin M SmithDepartment of Medicine, McGill University and McGill University Heath Center Research Institute, Montreal, Quebec, Canada.
Mary Beth BeasleyDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY.
Michelle LiDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Charles A PowellDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Corey E VentetuoloDepartments of Medicine and Health Services, Policy & Practice, Brown University, Providence, RI.
Maria PadillaDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

Funding

Tracking and Evaluation CoreU54GM115677 · NIGMS · BROWN UNIVERSITY · PI ROUNDS, SHARON IRENE SMITH · 2016 to 2025
$45.0M
Pulmonary Artery Endothelial Cell Endotypes and the Role of Anoikis Resistance in Pulmonary HypertensionR01HL174007 · NHLBI · RHODE ISLAND HOSPITAL · PI Olin D. Liang, Corey E Ventetuolo · 2025 to 2026
$1.3M
NHLBI NIH HHS R01 HL174007NIGMS NIH HHS U54 GM115677
6 · The paper itself

Abstract

Rationale: Small airways disease (SAD) and hyperinflation are common in precapillary pulmonary hypertension (PH). Activin signaling plays an important role in airway and bronchial function. Objective: To determine whether treatment with sotatercept, an activin signaling inhibitor, for severe precapillary PH is associated with improvements in physiologic markers of SAD and hyperinflation. Methods: We conducted a single-center, retrospective cohort study of participants who received sotatercept for the treatment of severe precapillary PH despite background PH treatments who also had pulmonary function tests (PFT) before and after initiation of sotatercept treatment. Measurements and Main Results: Forty-eight participants were included (median age 68 years, 77% female). Median BMI was 26.7 kg/m Conclusions: In a real-world cohort of patients with severe precapillary PH from a variety of causes, sotatercept was associated with improvements in markers of SAD and hyperinflation.

Indexed as

9.34 Pulmonary HypertensionClinical-Treatment

Identifiers

PMID41282909
PMCPMC12632688

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.